Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin
Harold A. Abramson, Anabela P. Rolo, B. Sklarofsky, J. Stache
The Journal of Psychology January 1, 1960 DOI: 10.1080/00223980.1960.9916396 via OpenAlex
Summary
AI-generated from the abstractIn a small human experiment, participants who developed tolerance to lysergic acid diethylamide also showed cross-tolerance to psilocybin, meaning prior exposure to one drug reduced the effects of the other. The authors suggest that these two hallucinogens act through a common mechanism in the brain to produce psychosis-like states. The study provides early evidence for shared pharmacological pathways between LSD and psilocybin.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Interventions | Lysergic acid diethylamide Psilocybin |
| Topics | LSD Psilocybin |
| Keywords | Psychosis Psychology Hallucinogen |
| Citations | 22 |
| Key finding | Cross-tolerance between LSD and psilocybin indicates they likely produce psychosis through a shared mechanism. |
Abstract
(1960). Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin. The Journal of Psychology: Vol. 49, No. 1, pp. 151-154.