Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism
Marcus W. Meinhardt, Simone Pfarr, Grégory Fouquet, Cathrin Rohleder, Manuela L. Meinhardt, Janet Barroso-Flores, Rebecca Hoffmann, Jérôme Jeanblanc, Elisabeth Paul, Konstantin Wagner, Anita C. Hansson, Georg Köhr, Nils Meier, Oliver von Bohlen Und Halbach, Richard L. Bell, Heike Endepols, Bernd Neumaier, Kai Schönig, Dušan Bartsch, Mickaël Naassïla, Rainer Spanagel, Wolfgang H. Sommer
Science Advances November 17, 2021 DOI: 10.1126/sciadv.abh2399 via OpenAlex
Summary
AI-generated from the abstractPsilocybin restores deficits in the metabotropic glutamate receptor 2 (mGluR2) caused by alcohol, which leads to the reversal of pathological behaviors associated with alcoholism.
Study at a glance
| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Intervention | Psilocybin |
| Topics | Addiction |
| Keywords | Prefrontal cortex Cognitive flexibility Neuroscience Craving Medicine |
| Citations | 92 |
| Key finding | Psilocybin rescues alcohol-induced mGluR2 deficits and reverses pathological behaviors in alcoholism. |
Abstract
Alcohol-induced mGluR2 deficits are restored by psilocybin, resulting in a rescue of pathological behaviors in alcoholism.