MDMA ("ecstasy") and neurotoxicity.

This work reviews evidence on whether MDMA (ecstasy) causes neurotoxicity in humans. The authors examine clinical and observational studies assessing the drug's effects on the brain's serotonin system. They conclude that MDMA use is associated with lasting changes in serotonergic function, including reduced serotonin transporter density and altered neurotransmitter activity, suggesting potential neurotoxic effects. However, the review notes limitations in human studies, such as confounding factors and lack of definitive causal evidence. The findings indicate that while MDMA can produce neurobiological alterations, the extent and clinical significance of neurotoxicity remain uncertain.

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Abstract

MDMA ("ecstasy") and neurotoxicity.