Dynamic coupling of whole-brain neuronal and neurotransmitter systems
Morten L. Kringelbach, Josephine Cruzat, Joana Cabral, Peter C. Whybrow, Nikos K. Logothetis, Gustavo Deco, Gitte M. Knudsen, Robin Carhart‐Harris
Proceedings of the National Academy of Sciences April 13, 2020 DOI: 10.1073/pnas.1921475117 via OpenAlex
Summary
AI-generated from the abstractBy combining multimodal neuroimaging data, a framework was developed that demonstrates the fundamental principles of bidirectional coupling between neuronal and neurotransmitter dynamical systems. The work causally explains the functional effects of stimulating specific serotoninergic receptors (5-HT2AR) with psilocybin in healthy humans. This could lead to a better understanding of why psilocybin shows promise as a therapeutic intervention for neuropsychiatric disorders such as depression, anxiety, and addiction.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Healthy humans |
| Intervention | Psilocybin |
| Topics | Addiction Anxiety Psilocybin Serotonin |
| Keywords | Neuroscience Neurotransmitter systems |
| Citations | 326 |
| Key finding | Stimulation of 5-HT2A receptors with psilocybin causally explains functional effects in the brain, providing insight into its therapeutic potential for neuropsychiatric disorders. |
Abstract
Significance In a technical tour de force, we have created a framework demonstrating the underlying fundamental principles of bidirectional coupling of neuronal and neurotransmitter dynamical systems. Specifically, in the present study, we combined multimodal neuroimaging data to causally explain the functional effects of specific serotoninergic receptor (5-HT 2A R) stimulation with psilocybin in healthy humans. Longer term, this could provide a better understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction.