Comprehensive detection of lysergic acid diethylamide (LSD) in forensic samples using carbon nanotube screen-printed electrodes.

A new electrochemical screening method using a multi-wall carbon nanotube screen-printed electrode combined with square wave voltammetry can detect LSD in forensic samples quickly and reliably. The method shows high stability, with less than 5% variation in measurements, a linear detection range from 0.16 to 40.0 μmol L-1, and a low detection limit of 0.05 μmol L-1. Tests with twenty-three other substances, including phenethylamines and other illicit drugs, demonstrate strong selectivity for LSD. This approach provides a sensitive, reproducible, and straightforward tool for preliminary identification of LSD in seized samples.

Study at a glance

Abstract

Lysergic acid diethylamide (LSD) is a prevalent psychoactive substance recognized for its hallucinogenic properties, often encountered in blotter papers for illicit consumption. Given that LSD ranks among the most widely abused illicit drugs globally, its prompt identification in seized samples is vital for forensic investigations. This study presents, for the first time, an electrochemical screening method for detecting LSD in forensic samples, utilizing a multi-wall carbon nanotube screen-printed electrode (SPE-MWCNT). The LSD detection process was optimized on SPE-MWCNT in a phosphate buffer solution (0.1 mol L-1, pH 12.0) using square wave voltammetry (SWV). The combined use of SPE-MWCNT with SWV displayed robust stability in electrochemical responses for both qualitative (peak potential) and quantitative (peak current) LSD assessment, with a relative standard deviation (RSD) of less than 5% across the same or different electrodes (N = 3). A linear detection range was established between 0.16 and 40.0 μmol L-1 (R2 = 0.998), featuring a low limit of detection (LOD) of 0.05 μmol L-1. Interference studies with twenty-three other substances, including groups of phenethylamines typically found in blotting papers (e.g., NBOHs and NBOMes) and traditional illicit drugs, were performed, revealing a highly selective response for LSD using the proposed method. Consequently, the integration of SPE-MWCNT with SWV offers a robust tool for qualitative and quantitative LSD analysis in forensic applications, providing rapid, sensitive, selective, reproducible, and straightforward preliminary identification in seized samples.