MDMA enhances positive affective responses to social feedback.

MDMA, a compound being studied for treating PTSD, increases positive feelings in response to social feedback, such as receiving likes or rejections in a dating-app-like task. In a double-blind, placebo-controlled trial with 36 healthy adults aged 18-40, a high dose of MDMA (1.5 mg/kg) boosted positive affective responses to both positive and negative social feedback, compared to placebo and methamphetamine. This suggests MDMA may enhance social connection by making social interactions feel more rewarding, which could explain its therapeutic benefits. Further research is needed to test these effects in clinical populations and with different types of social feedback.

Study at a glance

Abstract

The prosocial compound ± 3,4-methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has shown promise as an adjunct to psychotherapy in the treatment of post-traumatic stress disorder. MDMA increases positive responses to social images, and it has been suggested that the ability of MDMA to positively bias social perception may underlie its therapeutic efficacy as a psychotherapy adjunct. However, the effect of the compound on affective responses to positive or negative social feedback has not been tested. In this study, we aimed to test the effects of MDMA compared to placebo and the prototypical stimulant, methamphetamine (MA), on responses to positive and negative social feedback. This was a double-blind, placebo-controlled, crossover trial (NCT03790618), comparing the effects of two doses of MDMA (0.75 mg/kg, 1.5 mg/kg) to both placebo and MA (20 mg) on responses to a personalized social feedback task, similar to a dating app, in healthy adult volunteers ages 18-40 (N = 36, 18 women, 18 men). The high dose of MDMA increased positive affective responses to social feedback. These findings suggest one process by which MDMA may facilitate social connection. Further work is needed to understand how MDMA affects responses to more generalized types of social feedback and to understand these effects in clinical populations.