[Psychedelics in the field of chronic pain. A path to explore?].

Psychedelics are being investigated as a new therapeutic approach for chronic pain. They can influence the serotonergic system, which affects central pain sensitization. Ketamine, already used for chronic pain, can reduce pain, but more studies are needed on its long-term effectiveness. Classic psychedelics are also drawing interest for their potential analgesic, anti-inflammatory, and functional effects, though research is limited. These findings encourage further investigation.

Study at a glance

Abstract

Psychedelics are emerging as a therapeutic innovation in psychiatry and their use in chronic pain is worth exploring. In fact, they can modulate the serotonergic system, affecting central pain sensitization mechanisms. Ketamine, used for chronic analgesia, can lead to pain reduction, but additional studies are needed to assess its longterm effectiveness. "Classic" psychedelics are recently attracting renewed interest for their potential effects on chronic pain. Despite limited studies, evidence suggests analgesic benefits, an effect on inflammation, and potential impacts on certain functional disorders. These results pave the way for further research in this ever-evolving field.