A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics

Psychedelic substances may offer therapeutic benefits for psychiatric disorders by acting through specific cellular mechanisms. This review describes how these compounds primarily signal through the 5-HT2A receptor and promote neural plasticity via the TrkB-BDNF pathway. It also covers their effects on other receptors and pathways, as well as their potential anti-inflammatory properties. The work highlights a promising direction for developing new mental health treatments.

Study at a glance

Abstract

Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders. This review delves into the intricate cellular neurobiology of psychedelics, emphasizing their potential therapeutic applications in addressing the global burden of mental illness. It focuses on contemporary research into the pharmacological and molecular mechanisms underlying these substances, particularly the role of 5-HT2A receptor signaling and the promotion of plasticity through the TrkB-BDNF pathway. The review also discusses how psychedelics affect various receptors and pathways and explores their potential as anti-inflammatory agents. Overall, this research represents a significant development in biomedical sciences with the potential to transform mental health treatments.