Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.
Cong Zhang, Yibo Wang, Xiaohui Wang
ACS pharmacology & translational science July 11, 2025 DOI: 10.1021/acsptsci.5c00379 via PubMed
Summary
AI-generated from the abstractNeuropsychiatric disorders arise from disruptions in brain network dynamics that fall along a spectrum from order to complexity to chaos. Psychedelics may work therapeutically by increasing neural entropy, breaking maladaptive patterns, and enabling network reorganization. This framework focuses on dynamic remodeling of the brain's connectome rather than static molecular fixes, proposing that controlled neural destabilization and reconnection offers a new treatment strategy for psychiatric and neurological conditions.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Brain entropy Brain networks Circuit remodeling Neuropsychiatric disorders |
| Citations | 2 |
| Key finding | Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization, emphasizing dynamic connectome remodeling over static molecular correction. |
Abstract
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.