Metabolomic profiles impacted by brief mindfulness intervention with contributions to improved health.

A brief mindfulness intervention, integrative body-mind training (IBMT), significantly enhances metabolic profiles, promoting physical and mental health. In a trial with 42 participants, IBMT led to notable increases in glycine derivatives and phosphatidylcholine, while relaxation training showed no significant effects. Specific metabolic pathways related to amino acid and lipid metabolism, including sphingolipid and α-linolenic acid metabolism, were altered after IBMT. These results underscore the potential of mindfulness practices to influence health through metabolic regulation, paving the way for future health promotion strategies.

Study at a glance

Abstract

Mounting evidence indicates that mindfulness-based interventions improve physical and mental health. However, whether brief mindfulness intervention supports health benefits by regulating metabolic profiles is poorly understood. To address this gap, this randomized controlled trial compared ten 1-hour sessions of integrative body-mind training (IBMT) with relaxation training (RT) in 42 participants. Untargeted metabolomics was performed on fasting serum samples to investigate the physiological effects of the interventions on metabolic profiles. After IBMT, significant increases were observed in glycine derivatives, glutamate, and tetrahexosylceramide, while multiple sulfur containing compounds decreased. In contrast, RT yielded no significant intervention effects. A direct comparison between IBMT and RT revealed significant group differences in the levels of glycine, phosphatidylcholine, phosphatidylethanolamine, phosphoglycerol, phosphatidylserine, sphingomyelin derivatives, and α-linolenic acid. Further, pathway and enrichment analyses confirmed the effects of IBMT on amino acid and lipid metabolism with significant alterations to sphingolipid, α-linolenic acid, and linoleic acid metabolism as well as histidine and pyruvate metabolism. These findings suggest that IBMT can reprogram key metabolic pathways. In conclusion, this study offers insights into how a brief mindfulness intervention modulates metabolic profiles and highlights the potential of mindfulness-based interventions to promote health through metabolic regulation. These findings may guide the development of future mindfulness-based health promotion strategies.