Hallucinogenic N-methylated indolealkylamines in the cerebrospinal fluid of psychiatric and control populations.
L Corbett, S T Christian, R D Morin, F Benington, J R Smythies
The British journal of psychiatry : the journal of mental science February 1, 1978 DOI: 10.1192/bjp.132.2.139 via PubMed
Summary
AI-generated from the abstractLevels of dimethyltryptamine and O-methylbufotenine in cerebrospinal fluid were measured in people with acute schizophrenia and in surgical and neurological control groups. Some patients with schizophrenia showed higher levels of both amines than controls, but the differences in distribution were not statistically significant in the sample studied. The gas-chromatographic method used can detect these substances at the low picogram level.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Patients with acute schizophrenia and surgical and neurological controls |
| Citations | 49 |
| Key finding | Some schizophrenic patients have higher levels of dimethyltryptamine and O-methylbufotenine in cerebrospinal fluid than controls, but the differences did not reach statistical significance. |
Abstract
The incidence and quantities of dimethyltryptamine and O-methylbufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level.