Effects of diazepam and of serotonin agonists on hyponeophagia in rats.
Neuropharmacology April 1, 1982 DOI: 10.1016/0028-3908(82)90097-1 via PubMed
Summary
AI-generated from the abstractSerotonin agonists fenfluramine and 5-MeODMT increased hyponeophagia (suppression of feeding in a novel environment) in rats, while diazepam reduced it and counteracted the effects of both serotonin agonists. Diazepam appears to act downstream of serotonergic drugs in modulating this behavior.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male and female rats |
| Interventions | Fenfluramine 5-MeODMT Diazepam |
| Dose | 2 mg/kg fenfluramine, 2.5 mg/kg 5-MeODMT, 1 mg/kg diazepam |
| Citations | 53 |
| Key finding | Diazepam antagonized the hyponeophagia-enhancing effects of serotonin agonists fenfluramine and 5-MeODMT, suggesting it acts distally to serotonergic drugs. |
Abstract
The effects of serotonin agonists, fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (5-MeODMT, 2.5 mg/kg) on hyponeophagia were studied both alone and in combination with diazepam (1 mg/kg). Male and female rats were used but sex differences were not found. The serotonin agonists enhanced hyponeophagia while diazepam attenuated it and antagonised the actions of both serotonin agonists. These findings are discussed in connection with the serotonin hypothesis of benzodiazepine action with the conclusion that diazepam acts distally to serotonergic drugs on hyponeophagia.