Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior.
European journal of pharmacology March 3, 1992 DOI: 10.1016/0014-2999(92)90340-a via PubMed
Summary
AI-generated from the abstractA single injection of ibogaine (40 mg/kg) given to rats 19 hours before cocaine (20 mg/kg) made cocaine's effects stronger: it increased the rise in dopamine levels in the striatum and nucleus accumbens and boosted cocaine-stimulated motor activity. The authors note that while high cocaine doses can cause aversion through anxiety, it remains unknown whether this ibogaine-induced potentiation would also produce aversion and reduce cocaine addiction.
Study at a glance
| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Ibogaine Cocaine |
| Dose | 40 mg/kg i.p. ibogaine; 20 mg/kg i.p. cocaine |
| Citations | 59 |
| Key finding | Ibogaine pretreatment potentiated cocaine-induced increases in extracellular dopamine and motor activity in rats. |
Abstract
To investigate a possible basis for the proposed anti-addictive property of ibogaine, the effects of an ibogaine (40 mg/kg i.p.) pretreatment on in vivo neurochemical and motor effects induced by cocaine (20 mg/kg i.p.) were studied. Ibogaine, administered 19 h earlier, potentiated the increase in extracellular dopamine levels in striatum and nucleus accumbens as well as the stimulated motor activity induced by cocaine. Although high doses of cocaine can become aversive by producing an anxiogenic reaction, it is unknown whether the potentiation of cocaine's effects by ibogaine would also cause aversion and lead to a decrease in cocaine addiction.