Ibogaine interferes with the establishment of amphetamine place preference learning.
Experimental and clinical psychopharmacology May 1, 1997 DOI: 10.1037//1064-1297.5.2.119 via PubMed
Summary
AI-generated from the abstractA single injection of ibogaine given 24 hours before amphetamine prevented the formation of a conditioned place preference for amphetamine after one or two conditioning trials, but was less effective after four trials. The reduced effectiveness with more trials appears due to tolerance developing to ibogaine.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ibogaine |
| Citations | 11 |
| Key finding | Ibogaine blocked amphetamine-induced place preference after one or two conditioning trials but was less effective after four trials, likely due to tolerance to ibogaine. |
Abstract
The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.