Alteration in Electroencephalogram and Monoamine Concentrations in Rat Brain following Ibogaine Treatment.
Zbigniew Binienda, Michael A Beaudoin, Brett T Thorn, D Rebecca Prapurna, John R Johnson, C Matthew Fogle, William Slikker, Syed F Ali
Annals of the New York Academy of Sciences May 1, 1998 DOI: 10.1111/j.1749-6632.1998.tb08241.x via PubMed
Summary
AI-generated from the abstractIbogaine, a psychoactive alkaloid with antiaddictive properties, can cause neurotoxicity. In anesthetized rats, a single 50 mg/kg dose of ibogaine produced an immediate decrease in heart rate and reduced EEG power across delta, theta, alpha, and beta frequency bands during the first 30 minutes, with recovery within 15 minutes. In the caudate nucleus, dopamine levels fell while dopamine turnover increased; serotonin levels rose in the frontal cortex. These physiological changes likely stem from ibogaine's interactions with multiple neurotransmitter systems.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats anesthetized with isoflurane |
| Intervention | Ibogaine |
| Dose | 50 mg/kg |
| Duration | 2 hours of EEG recording after injection |
| Topics | Ibogaine |
| Keywords | Neuropharmacology Addiction treatment Physiological effects Animal study |
| Citations | 13 |
| Key finding | Ibogaine administration in rats caused an immediate decrease in heart rate and a transient reduction in EEG power across multiple frequency bands, along with decreased dopamine and increased serotonin turnover in specific brain regions. |
Abstract
Ibogaine (IBO) is a psychoactive indole alkaloid that has antiaddictive properties. However, treatment with IBO may lead to neurotoxicity, since IBO and its metabolites interact persistently with many neurotransmitter systems. Here, we recorded cortical electroencephalogram (EEG) signals from rats anesthetized with isoflurane. The heart rate (HR) was monitored via electrocardiogram (EKG) electrodes. After the baseline EEG was recorded, rats received one intraperitoneal (i.p.) dose of 50 mg/kg IBO. EEG signals were recorded for 2 hr. Rats were then sacrificed and brains dissected into frontal cortex (FC), caudate nucleus (CN), hippocampus (HIP), and brain stem (BS). The level of dopamine (DA), serotonin (5-HT), and their metabolites were determined by high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Compared with baseline, a decrease in HR immediately after IBO injection and a decrease in δ, θ, α, and β power spectra frequency bands (1-4, 4-8, 8-13, 13-32Hz) during the first 30 min after IBO administration was observed. EEG recovered within the next 15 min. In CN, the level of DA decreased and DA turnover rate increased significantly. The levels of 5-HT increased in FC. The pattern of EKG and EEG response to IBO may be due to multiple receptor interactions of IBO.