Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.
X Yu, S Z Imam, G D Newport, W Slikker, S F Ali
Brain research March 27, 1999 DOI: 10.1016/s0006-8993(99)01154-3 via PubMed
Summary
AI-generated from the abstractIn female C57BL/6N mice, methamphetamine caused a rise in body temperature and increased levels of a stress protein (HSP-72) in the caudate nucleus. Ibogaine alone lowered body temperature. When ibogaine was given before methamphetamine, it completely prevented the hyperthermia and reduced HSP-72 expression. These results suggest ibogaine can block methamphetamine-induced brain stress and temperature changes.
Study at a glance
| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Population | Female C57BL/6N mice |
| Interventions | Ibogaine Methamphetamine |
| Dose | 50 mg/kg ibogaine, 20 mg/kg methamphetamine |
| Duration | 48 hours after methamphetamine injection |
| Keywords | Ibogaine: ibogaine This compound Methamphetamine: methamphetamine Counteract methamphetamine's impact Protection |
| Citations | 17 |
| Key finding | Pretreatment with ibogaine completely blocked methamphetamine-induced hyperthermia and HSP-72 expression in the striatum. |
Abstract
Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment with ibogaine can completely block methamphetamine-induced hyperthermia and HSP-72 expression in the striatum.