A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A.
Kevin Tidgewell, Wayne W Harding, Mark Schmidt, Kenneth G Holden, Daryl J Murry, Thomas E Prisinzano
Bioorganic & medicinal chemistry letters October 18, 2004 DOI: 10.1016/j.bmcl.2004.07.081 via PubMed
Summary
AI-generated from the abstractSalvinorin A, a hallucinogen from Salvia divinorum, may serve as a therapeutic for stimulant abuse, but no methods exist to detect it or its metabolites in biological fluids. This work describes a straightforward synthesis of a deuterium-labeled analog of salvinorin A and its use as an internal standard for detecting salvinorin A and its metabolites in biological fluids using LC-MS, providing a tool for studying its metabolism and potential therapeutic development.
Study at a glance
| Characteristics | Method development Peer reviewed |
|---|---|
| Topics | Salvia divinorum |
| Keywords | Drug metabolism Analytical methods Therapeutic potential |
| Citations | 68 |
| Key finding | A deuterium-labeled analog of salvinorin A was synthesized and can be used as an internal standard for LC-MS detection of salvinorin A and its metabolites in biological fluids. |
Abstract
Salvinorin A is a novel hallucinogen isolated from the widely available leaves of Salvia divinorum. Based on its mechanism of action, salvinorin A has shown potential as a stimulant abuse therapeutic. However, there are no methods for the detection of salvinorin A or its metabolites in biological fluids. In order to begin developing salvinorin A as a potential therapeutic, an understanding of its metabolism is needed. Here, a straightforward synthesis of a deuterium labeled analog of salvinorin A and its utility as an internal standard for the detection of salvinorin A and its metabolites in biological fluids by LC-MS is described.