Recurrent seizures and serotonin syndrome following "2C-I" ingestion.
Adam Bosak, Frank Lovecchio, Michael Levine
Journal of medical toxicology : official journal of the American College of Medical Toxicology June 1, 2013 DOI: 10.1007/s13181-013-0287-x via PubMed
Summary
AI-generated from the abstractA 19-year-old male who insufflated the designer drug 2C-I developed recurrent seizures, hyperadrenergic state, and serotonin syndrome, leading to prolonged respiratory failure. Comprehensive drug testing confirmed 2C-I. The patient ultimately made a full recovery. This case highlights the potential for severe toxicity from this emerging phenethylamine, with effects including seizures and serotonin syndrome, and underscores the need for awareness among clinicians.
Study at a glance
| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 19-year-old male who insufflated 2C-I |
| Keywords | 2c-i toxicity 2c-i poisoning 2c-i adverse effects 2c-i overdose 2c-i reactions |
| Citations | 59 |
| Key finding | Insufflation of 2C-I can cause recurrent seizures, serotonin syndrome, and prolonged respiratory failure, with the possibility of full recovery. |
Abstract
The phenethylamines, including 2, 5 dimethoxy-4-iodophenethylamine, commonly referred to as 2C-I, have recently emerged as a new class of designer drugs. Cases of toxicity from these drugs are not well described in the literature. This case report describes a 19 year-old male who insufflated 2C-I. Following the ingestion, the patient developed recurrent seizures, and was taken to the emergency department, where he was noted to be hyperadrenergic and had recurrent seizures. The patient was diagnosed with serotonin syndrome and experienced prolonged respiratory failure, although he ultimately made a full recovery. Comprehensive drug testing revealed the presence of 2C-I. The pharmacologic properties of 2C-I are also discussed.