Open MIND
January 1, 2026
Yang Wan
The Multi-Cognitive Regime Architecture (MCRA) V5 reconceptualizes the mind as a dynamic runtime system rather than a static module structure. It defines seven cognitive regimes—integrative, homeostatic, social-norm, logical-reasoning, adaptive-neural, affective-anchoring, and perceptual-encoding memory—each a distinct runtime configuration of the same neural hardware. Hebb's Rule serves as the meta-rule: all cognitive structures are shaped by experience through the same plasticity mechanism. The framework provides unified mechanistic explanations across dreaming, Dissociative Identity Disorder, major depression, and LLM hallucinations. It generates independent, operational falsifiability conditions for all seven regimes, advancing the theory from a philosophical proposal to a testable scientific hypothesis.
Open MIND
January 1, 2025
Zhu, Xudong
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Open MIND
April 23, 2018
John Makeham
The origin of moral badness is a central problem in New Confucian philosopher Xiong Shili's 1959 work Explaining the Mind. Xiong argues that Buddhists never addressed the origin of ignorance and delusion, which cause suffering and wrongdoing, and he attempts to remedy this. The essay shows that Xiong's conceptual structure for explaining badness through nature (xing) and mind (xin) is isomorphic with that of Zhu Xi, a Song dynasty Confucian. This isomorphism suggests Xiong consciously drew on Zhu Xi and the Buddhist models that Zhu used. Evidence demonstrates that even late in life, despite his criticisms of Buddhism, Xiong continued to rely on Buddhist philosophy of mind.
Open MIND
January 1, 2015
Jonathan Cachat, Chris Collins, Evan J. Kyzar et al.
Three-dimensional reconstructions of zebrafish swimming paths enable both macro- and micro-level analysis of behavior, offering a more complete picture than traditional 2D traces. Temporal 3D reconstructions plot spatial data across time to reflect activity over testing, while spatial 3D reconstructions use two cameras to depict activity within the actual arena. These reconstructions are highly sensitive to anxiolytic, anxiogenic, and hallucinogenic effects in adult zebrafish. For example, ibogaine reversed natural behaviors, a characterization impossible without 3D reconstructions. Track3D, applied for the first time in adult zebrafish, showed strong significant correlation (R>0.07) of automated endpoints with manual data, providing precise calculation of movement parameters and accurate spatiotemporal integration. These approaches permit advanced movement pattern analysis for screening psychoactive compounds.
Open MIND
October 1, 2012
Thomas John Mcconochie
Many sinologists have labeled Zhuangzi's writings as mystical, but they do so without engaging the scholarly literature on mysticism. This analysis examines three specific passages from the Zhuangzi—the "riding the wind" section, the "Ziqi" dialogue, and the "sitting and forgetting" dialogue—to provide an explicit hermeneutic for understanding mysticism in the text. The proposed hermeneutic holds that mystical experiences transcend ego and sensory perception through esoteric practices involving ecstasy, leading the practitioner to experience what they consider the true nature of reality. The ecstatic experience of the egoless state itself is more central to mystical experience than unity with a divine other, which is absent from two of the three passages analyzed.
Open MIND
January 1, 2003
Jonathan Freedlander
Ibogaine, a naturally occurring compound, is being studied for treating addictions to opiates, cocaine, alcohol, and nicotine, as current therapies show limited effectiveness. This paper reviews research on ibogaine's history, pharmacokinetics, pharmacodynamics, toxicology, and therapeutic effectiveness for substance use disorders.