Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling
Journal of Neuroscience November 18, 2009 Angela R. Laird, Simon B. Eickhoff, Karl Li et al. 577 citations
The default mode network (DMN) is a set of brain regions active at rest and less active during many tasks, but these regions also show task-related increases. By combining activation likelihood estimation meta-analysis with the BrainMap database, core DMN regions were identified and their functional heterogeneity examined. Meta-analytic coactivation maps showed each region connects with both DMN and non-DMN areas. Behavioral domain analysis revealed that DMN subnetworks are differentially specialized: affective, perceptual, and motor-processing cliques were identified. The results provide a connectivity model of DMN interactions during diverse tasks.