Ketamine activates psychosis and alters limbic blood flow in schizophrenia
Neuroreport April 1, 1995 Adrienne C. Lahti, Henry H. Holcomb, Deborah R. Medoff et al. 440 citations
A subanesthetic dose of the NMDA antagonist ketamine temporarily activated psychotic symptoms in people with schizophrenia, closely resembling their usual episodes. In a PET study using radioactive water, ketamine increased blood flow in the anterior cingulate cortex and decreased flow in the hippocampus and primary visual cortex. These findings support the idea that altered glutamate transmission may contribute to schizophrenia and PCP-induced psychosis.