Gender Differences in Suicidal and Self-Harming Responses to Esketamine: A Real-World Retrospective Study
Current Neuropharmacology October 20, 2025 Vassilis Martiadis, Fabiola Raffone, Danilo Atripaldi et al. 21 citations
A single dose of esketamine quickly reduced suicidal thoughts and depression in people with treatment-resistant depression. Preliminary evidence suggests that men and women may respond differently, indicating that personalized treatment approaches could improve results. More research is needed to confirm these gender differences, examine long-term effects, and understand the biological reasons behind them.