Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications.
Brain Sci January 25, 2025 Francesco Weiss, Anna Magnesa, Matteo Gambini et al. 62 citations
Psychedelics show promise for treating mental disorders, but their use remains controversial. Preclinical evidence from genetic, histological, and behavioral studies consistently indicates that psychedelics can induce neuroplasticity. Clinical evidence, despite methodological challenges, generally aligns with these preclinical findings. However, it remains unclear whether the neuroplastic effects of classic psychedelics can be separated from their psychodysleptic effects, which could reduce associated psychopathological risks. Additionally, the assumption that a 'relaxation of priors' is always beneficial is debatable. Further research is needed to clarify indications and contraindications for psychedelic psychoplastogens within a precision medicine framework.