Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology December 1, 2023 Isabelle Straumann, Laura Ley, Friederike Holze et al. 41 citations
Co-administering MDMA (100 mg) with LSD (100 µg) does not improve the quality of the acute subjective effects compared with LSD alone in healthy adults. The combination prolongs the duration of subjective effects and increases blood pressure, heart rate, and pupil size more than LSD alone. Oxytocin levels rise more with MDMA alone or the combination than with LSD alone. The findings suggest that combining MDMA with LSD offers no relevant benefits over LSD alone for psychedelic-assisted therapy.