LSD treatment improved performance in a novel object recognition task in rats and a visuo-spatial memory task in humans. A proteomic analysis of human brain organoids showed that LSD affected metabolic pathways associated with neural plasticity, including mTOR. Simulations using a neural network model of a cortico-hippocampal circuit, with baseline plasticity strength as a proxy for age and increased plasticity related to LSD dose, fit the experimental data well. The results suggest that LSD has nootropic effects.
A new method directly estimates a unique entropy from a Pearson correlation matrix without requiring arbitrary thresholding. The approach rescales the matrix so it satisfies conditions for a von Neumann-like entropy. The method is demonstrated on neuroimaging time series from human brains under a psychedelic.