Whole-brain modelling supports the use of serotonergic psychedelics for the treatment of disorders of consciousness
bioRxiv Preprint Server December 29, 2023 I Mindlin, R Herzog, L Belloli et al. 7 citations preprint
Disorders of consciousness involve impaired awareness with few non-invasive treatment options. Researchers used computer models to simulate how activating certain receptors, particularly serotonergic and opioid receptors, alters whole-brain dynamics in patients. The simulations shifted patients' brain activity patterns toward those seen in conscious, awake individuals. This effect depended on the density of activated receptors across the brain. The results suggest whole-brain modeling can help identify new pharmacological treatments and support the potential of serotonergic psychedelics to accelerate recovery of consciousness.