Bo Ma

2 papers in the library · publishing 2021-2026

Papers

Acute Effects of Esketamine on the EEG Power Spectrum and Signal Complexity in Prolonged Disorders of Consciousness: A Prospective Exploratory Cohort Study.

Journal of neurosurgical anesthesiology June 15, 2026 Yi Liang, Wanning Yang, Xinxin Wang et al.

In patients with prolonged disorders of consciousness, a one-hour intravenous infusion of esketamine (0.3 mg/kg/h) altered brain activity as measured by electroencephalography. The drug suppressed delta wave power while increasing beta and gamma wave power across the whole brain, and increased alpha wave power specifically in patients diagnosed as vegetative state/unresponsive wakefulness syndrome. Signal complexity, measured by Lempel-Ziv complexity, increased in the parietal and occipital brain regions. In minimally conscious patients, this complexity increase persisted for 30 minutes after the infusion stopped, while changes were transient in vegetative state patients. However, these neurophysiological changes were not accompanied by any improvements in behavioral responsiveness as assessed by the Coma Recovery Scale-Revised.

DOI: 10.1097/ana.0000000000001124 Full text Esketamine Lempel-ziv complexity Electroencephalography Power spectral density

Dynamic Reconfiguration of Human Brain Networks Across Altered States of Consciousness.

Behavioural Brain Research November 1, 2021 Haiyang Liu, Ke-Hui Hu, Yingjie Peng et al.

During dexmedetomidine-induced sedation, the brain's functional networks become more fragmented and dynamic, with increased switching rates and decreased integration compared to wakefulness; these changes largely reverse upon recovery of consciousness. The study tracked dynamic network reconfiguration using fMRI data from 21 healthy subjects and multilayer network analysis, comparing wakefulness, sedation, and recovery states. The findings suggest that altered states of consciousness involve a whole-brain pattern of higher modular dynamics and more fragmented communication, offering insights into the neural basis of consciousness and potential clinical relevance for disorders of consciousness.

DOI: 10.1016/j.bbr.2021.113685 Medicine