Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.
Scientific reports October 14, 2023 Nathalie M Rieser, Ladina P Gubser, Flora Moujaes et al. 14 citations
Psilocybin alters cerebral blood flow in the brain, and the magnitude of these changes depends on individual baseline psychological and neurobiological characteristics. In a placebo-controlled study of 70 healthy participants given one of three oral doses of psilocybin, reductions in relative cerebral blood flow correlated with both baseline traits and the intensity of the subjective psychedelic experience. The findings demonstrate that inter-individual heterogeneity in the neural response to psilocybin is linked to pre-existing differences, helping to identify biomarkers for a personalized medicine approach in psychedelic-assisted therapy.