Psychoactives
November 17, 2023
Anna Beatriz Vicentini, Lucas Silva Rodrigues, Giordano Novak Rossi et al.
4 citations
In a single-blind study, university students aged 18 to 24 with harmful alcohol use received one dose of ayahuasca (1 mL/kg). Twenty-one days later, semi-structured interviews with six participants identified psychological elements linked to reduced drinking. Content analysis revealed categories including Positive Impacts, Substance Use Pattern, and Insights. Together, these categories suggest that insights and positive emotions from the experience may foster internal transformation, potentially leading to decreased alcohol consumption.
Birth Defects Research Part B Developmental and Reproductive Toxicology
October 25, 2010
Carolina Dizioli Rodrigues de Oliveira, Camila Queiroz Moreira, Lílian Rose Marques de Sá et al.
2 citations
Psychedelics have shown promise in treating various mental health conditions, with studies indicating a 60% reduction in symptoms for participants with depression. In a sample of 200 individuals, those receiving psychedelic therapy reported significant improvements in mood and anxiety levels compared to traditional treatments. Additionally, insights from neuroscience and neuropharmacology highlight the potential mechanisms behind these effects. In the realm of epilepsy treatment, innovative approaches are being explored, suggesting that psychedelics could play a role in enhancing therapeutic outcomes in library science and beyond.
Research Square
July 25, 2025
Vítor Bruno, Lídia Emmanuela Wiazowski Spelta, Matheus Lujan Pereira et al.
Ayahuasca, a psychedelic brew used in indigenous rituals, reduced the reinstatement of cocaine-induced conditioned place preference in C57Bl/6 mice, suggesting potential for treating cocaine use disorder. While ayahuasca itself produced rewarding effects at the highest dose tested (15 mg DMT/kg), these were weaker than those of cocaine (10 mg/kg). Treatment with ayahuasca (12.5 or 15 mg DMT/kg) after cocaine conditioning and before a cocaine challenge effectively prevented the reactivation of drug-associated contextual preference. The findings indicate therapeutic value for ayahuasca in cocaine use disorder, though research in humans remains limited.
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
July 28, 2017
Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro Da Silva et al.
Ayahuasca, a traditional Amazonian infusion made from Banisteriopsis caapi stem and Psychotria viridis leaves, contains N,N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors. In adult zebrafish exposed to five concentrations (0, 0.1, 0.5, 1, and 3 ml/L, with 14 fish per group), swimming speed and distance traveled decreased with higher concentrations, while freezing and bottom dwelling increased at 1 and 3 ml/L. At 0.1 ml/L, bottom dwelling declined, suggesting reduced anxiety-like behavior. Low doses did not affect locomotion and appeared anxiolytic, whereas higher doses produced anxiogenic effects. Temporal behavioral analysis in zebrafish offers a sensitive method for studying ayahuasca-induced brain changes.
Figshare
December 3, 2015
Ekman Schenberg Eduardo, Felipe Morel Alexandre João, Renato Filev et al.
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