Jessica Kwee

2 papers in the library · 3 citations · publishing 2025-2026

Papers

PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour

bioRxiv (Cold Spring Harbor Laboratory) April 14, 2025 Leonardo Novelli, Devon Stoliker, Tamrin Barta et al. 3 citations preprint

PsiConnect is a large-scale neuroimaging study that examined brain activity in 62 participants before and after a 19 mg dose of psilocybin using functional, structural, and diffusion-weighted MRI combined with EEG. The design included resting-state scans and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the participants completed an 8-week meditation training program, allowing exploration of interactions among meditation, psilocybin, and brain function. Multi-echo fMRI improved signal-to-noise ratio and reduced artifacts. Behavioral and self-report measures captured acute and longitudinal effects, with follow-ups extending to one year. The data is curated according to open science principles.

DOI: 10.1101/2025.04.11.643415 Full text Psilocybin Neuroscience Neuroimaging Hallucinogen +1

PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin.

Scientific data May 21, 2026 Leonardo Novelli, Devon Stoliker, Tamrin Barta et al.

PsiConnect is a large-scale neuroimaging study that investigates how psilocybin affects brain activity and subjective experience depending on context. Sixty-two participants received a 19 mg dose of psilocybin and underwent functional, structural, and diffusion-weighted MRI, as well as EEG, before and after administration. Scans included resting-state and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the participants completed an 8-week meditation training program, allowing examination of interactions between meditation, psilocybin, and brain function. Multi-echo fMRI improved signal quality. Behavioral and self-report measures captured acute and long-term effects, with follow-ups up to one year. Data is openly shared to support future research.

DOI: 10.1038/s41597-026-07312-1 Full text