Wei Xiong

2 papers in the library · publishing 2017-2026

Papers

Cannabidiol Mitigates Ketamine-Induced Hyperlocomotion Via Allosteric Potentiation of Ventral Tegmental Glycine Receptor α1 Signaling.

Biological psychiatry March 16, 2026 Xianglian Wang, Jing Xia, Heyi Luo et al.

Ketamine produces rapid antidepressant effects but also causes hyperlocomotion, a side effect linked to increased dopamine activity in the ventral tegmental area (VTA). Cannabidiol (CBD) blocked ketamine-induced hyperlocomotion in mice when given systemically (30 mg/kg) or directly into the VTA (10 μg per mouse). Whole-brain imaging showed that ketamine increased neuronal activity in the VTA, prefrontal cortex, and nucleus accumbens, which CBD reduced. Electrophysiology revealed that ketamine suppressed glycine receptor (GlyR) function, while CBD reversed this dysfunction by antagonizing ketamine-driven delays in GlyR activation. In GlyRα1S296A mice, CBD's effect on hyperlocomotion was abolished, indicating that VTA GlyRα1 signaling, particularly the S296 residue, is essential for CBD's dissociation of ketamine's therapeutic and adverse effects.

DOI: 10.1016/j.biopsych.2026.03.992 Full text Cannabidiol Ketamine Antidepressant Glycine receptor +2

Neural Correlates of Consciousness at Near-Electrocerebral Silence in an Asphyxial Cardiac Arrest Model.

Brain connectivity April 1, 2017 Donald E Lee, Lauren G Lee, Danny Siu et al.

During asphyxial cardiac arrest in rats, the brain's electrical activity passes through four distinct stages before electrocerebral silence. A transient period of near-electrocerebral silence lasting several seconds is linked to a significant increase in frontal coherence between left and right motor cortices, with no corresponding increase in power. This stage also shows a significant posterior shift of electrographic power toward the visual cortices. These distinctive neural features—a burst in frontal coherence and posterior power shift—may be neural correlates of conscious processing in the dying brain.

DOI: 10.1089/brain.2016.0471 Full text Cardiac arrest Coherence Connectivity Consciousness +2