Hyoung-Chun Kim

2 papers in the library · 10 citations · publishing 2018-2021

Papers

New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents.

Archives of toxicology April 1, 2021 Young-Jung Kim, Shi-Xun Ma, Kwang-Hyun Hur et al. 10 citations

The drugs 2C-C and 2C-P, members of the 2C family of phenethylamines, show abuse potential and neurotoxic effects at high doses in animal models. In mice, both drugs produced conditioned place preference in a dose-dependent manner and increased self-administration in rats, indicating abuse potential. High doses decreased locomotor activity, rota-rod performance, and scores on memory tests (Y-maze, novel object recognition, passive avoidance). The drugs altered expression of D1 and D2 dopamine receptors, the dopamine transporter, and its phosphorylated form in the nucleus accumbens and medial prefrontal cortex, and increased c-Fos-positive cells in the nucleus accumbens. High doses also activated microglia, suggesting neuroinflammation in the striatum.

DOI: 10.1007/s00204-021-02980-x Full text 2c-c 2c-p Neurotoxicity Designer drugs +18

Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.

Brain research bulletin March 1, 2018 The-Vinh Tran, Se Jin Park, Eun-Joo Shin et al.

Repeated treatment of mice with phencyclidine (PCP), a drug that induces schizophrenia-like symptoms, increased expression of the platelet-activating factor receptor (PAF-R) in the prefrontal cortex and hippocampus, with a greater increase in the prefrontal cortex. This was accompanied by increased activity of the proinflammatory molecule nuclear factor kappa B (NF-κB). Blocking PAF-R with the antagonist ginkgolide B, using PAF-R knockout mice, or inhibiting NF-κB with pyrrolidine dithiocarbamate each reduced PCP-induced abnormal behaviors including reduced sociability, depression, cognitive impairment, and behavioral sensitization. The findings suggest PAF-R drives PCP-induced neuropsychotoxicity through an NF-κB-dependent mechanism and may be linked to schizophrenia-like behavior.

DOI: 10.1016/j.brainresbull.2017.11.004 Full text Phencyclidine Platelet-activating factor receptor Schizophrenia