Anthony Cleare

2 papers in the library · 24 citations · publishing 2024-2025

Papers

A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.

Npj Ment Health Res July 2, 2024 Ronit Kishon, Nadav Liam Modlin, Yael M. Cycowicz et al. 22 citations

Before psychedelics were prohibited, clinical research with complex psychiatric patients developed diverse treatment methods and practices that remain relevant today. These early studies, though lacking modern rigor, recognized that the treatment context and clinician's role are essential for positive outcomes. This review examines pre-prohibition clinical narratives about the phenomenology of psychedelic treatment and non-pharmacological factors in patient experience. It also explores clinician perspectives and psychological interventions from that era to inform future research directions and best practice guidelines for modern psychedelic research and clinician training.

DOI: 10.1038/s44184-024-00068-9 Full text Psychedelic therapy Mental health treatment Clinical research Alternative medicine +1

Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatment.

EClinicalMedicine December 1, 2025 Nadav Liam Modlin, Victoria Williamson, Guy M Goodwin et al. 2 citations

Psilocybin treatment for post-traumatic stress disorder, when delivered with standardized preparation and support, may allow patients to engage with trauma-related material indirectly through affective, somatic, and self-transcendent experiences, such as feelings of unity or dissolution of self, rather than requiring direct confrontation with traumatic memories as in standard therapies. This qualitative study, nested within a phase 2 trial involving 21 adults with PTSD, identified four core themes: non-pharmacological factors for psychological safety and trust, the experiential nature of psilocybin treatment, engagement with trauma-related material, and comparative reflections on prior therapies. The findings suggest psilocybin offers a meaningful therapeutic opportunity, but larger controlled studies are needed.

DOI: 10.1016/j.eclinm.2025.103692 Full text Post-traumatic stress disorder Psychedelic therapy Comp360 psilocybin Patient experience +1