The British journal of psychiatry : the journal of mental science
July 11, 2025
Tor-Morten Kvam, Ivar W Goksøyr, Justyna Rog et al.
6 citations
In an open-label study of twelve adults with moderate to severe major depressive disorder, two sessions of MDMA-assisted therapy one month apart, combined with psychotherapy, led to a substantial average reduction of 19.3 points on the Montgomery-Asberg Depression Rating Scale and an average decrease of 11.7 points on the Sheehan Disability Scale, indicating improved daily functioning. No serious or unexpected adverse events occurred. The results suggest the approach is safe and feasible, with strong indications of efficacy, though randomized controlled trials are needed to confirm.
Journal of Psychiatric Research
November 27, 2025
Tor-Morten Kvam, Ivar W Goksøyr, Joanna Róg et al.
3 citations
In a small long-term follow-up of twelve people with major depressive disorder, MDMA-assisted therapy—two MDMA dosing sessions combined with nine psychotherapy sessions—led to sustained reductions in depression severity and disability seven months after baseline. Depression scores on the Montgomery-Asberg Depression Rating Scale and disability scores on the Sheehan Disability Scale remained significantly lower than before treatment, with no significant changes from the immediate post-treatment visit. Suicidal ideation did not exceed pre-study levels. The results suggest lasting treatment effects and safety, though the authors call for larger controlled trials to confirm these preliminary findings.
Tidsskr Nor Laegeforen
June 10, 2026
Tor-Morten Kvam, Ivar W. Goksøyr, Lowan H. Stewart et al.
The abstract notes that MDMA is used both clinically and non-clinically, but provides no further details about the nature, extent, or findings of such use.
Br J Psychiatry
March 6, 2026
Tor-Morten Kvam, Ivar Walderhaug Goksøyr, Justyna Rog et al.
No Summary
Br J Psychiatry
February 10, 2026
Tor-Morten Kvam, Ivar W. Goksøyr, Justyna Rog et al.
No Summary