Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent.
Life sciences September 19, 2003 Stephen I Deutsch, Richard B Rosse, Eddie N Billingslea et al.
The NMDA receptor antagonist MK-801 (dizocilpine) induces intense, irregular jumping behavior (popping) in mice, modeling NMDA receptor hypofunction implicated in schizophrenia. Galantamine, which enhances nicotinic neurotransmission through acetylcholinesterase inhibition and positive allosteric modulation, significantly reduced MK-801-elicited popping at a dose of 100 mg/kg. This demonstrates that nicotinic interventions can influence NMDA receptor-mediated neurotransmission in mice, supporting the potential of nicotinic modulation as a therapeutic strategy for schizophrenia.