Cannabis use and attenuated positive and negative symptoms in youth at clinical high risk for psychosis.
Schizophrenia Research August 25, 2022 Olga Santesteban-Echarri, Lu Liu, Madeline Miller et al.
Youth at clinical high-risk for psychosis report more lifetime, past-six-month, and baseline cannabis use than healthy controls, along with greater frequency, severity, and rates of cannabis use disorder. Among high-risk youth, those who use cannabis show higher baseline grandiosity and lower social anhedonia at 12 months. Cannabis use severity was unrelated to clinical status at two years and did not distinguish those who later developed psychosis from those who did not. The small number of cannabis users in the high-risk group limited statistical power.