Altered Functional Connectivity Dynamics Serving Cognitive Flexibility in Regular Cannabis Users.
Addiction biology February 1, 2025 Kellen M McDonald, Mikki Schantell, Jason A John et al.
Chronic cannabis use is linked to altered coordination between visual brain regions and the ventral attention network during cognitive flexibility tasks. Twenty-five chronic users and 30 non-users completed a task-switch paradigm while undergoing magnetoencephalography. Users showed modified associations between functional connectivity switch costs and behavioral switch costs along pathways connecting visual cortices and attention-related regions, within theta, alpha, and gamma frequency ranges. These findings indicate that cannabis use is associated with changes in how brain networks communicate during tasks requiring cognitive flexibility, particularly involving visual and executive function areas.