Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
Journal of Neuroscience Research March 3, 2023 Veronika Langová, Petra Horká, Jan Hubený et al. 10 citations
Ketamine, an NMDA receptor antagonist, disrupted electric signaling and navigation in the weakly electric fish Gnathonemus petersii, a candidate model for schizophrenia. Lower doses increased locomotion and erratic movement, while higher doses reduced electric organ discharges, indicating positive schizophrenia-like symptoms. A low dose of haloperidol did not normalize these symptoms, suggesting further testing with more antipsychotic doses is needed to confirm the model's predictive validity.