Three regulatory compliant test systems show no signs of MDMA-related genotoxicity
Journal of Psychopharmacology August 31, 2021 Isaac Cohen, Laken Barber, Tyson Paul Dubnicka et al. 1 citation
3,4-Methylenedioxymethamphetamine (MDMA)-assisted therapy is highly effective for posttraumatic stress disorder (PTSD). Previous research on MDMA's potential to damage DNA (genotoxicity) has been inconclusive. Three regulatory-compliant studies—a bacterial reverse mutation (Ames) assay, a chromosome aberration test in Chinese hamster ovary cells, and an in vivo micronucleus study in male Sprague Dawley rats—found that MDMA did not cause genotoxic effects at or above clinically relevant concentrations.