Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence
Psychiatry Research January 14, 2020 Clemens Bauer, Kana Okano, Satrajit Ghosh et al. 87 citations
Auditory hallucinations in schizophrenia are linked to overactivity and hyperconnectivity in the default mode network and reduced anticorrelation with the central executive network. Patients were trained with real-time fMRI neurofeedback and meditation strategies to modulate these networks. The intervention reduced default mode network hyperconnectivity and increased anticorrelation between the default mode and central executive networks. Changes in individual default mode network connectivity correlated with reductions in auditory hallucination frequency and severity. This provides the first empirical evidence that meditation-enhanced neurofeedback can directly alter resting state network activity and reduce auditory hallucinations.