Zexuan Li

2 papers in the library · publishing 2022-2023

Papers

Empirical evidence for the neurocognitive effect of nitrous oxide as an adjunctive therapy in patients with treatment resistant depression: A randomized controlled study.

Psychiatry research August 1, 2023 Jin Liu, Xiaotian Zhao, Xiyu Wei et al.

A double-blinded, placebo-controlled randomized trial tested whether nitrous oxide (N2O) improves cognitive function in 44 patients with treatment-resistant depression. Thirty-four patients completed cognitive tests before treatment and at 1 and 2 weeks after a one-hour inhalation of 50% N2O/50% oxygen or placebo (50% air/50% oxygen). Although N2O did not produce a significant antidepressant effect at 1 week, patients who received N2O showed better executive function at 1 week compared with placebo, and this improvement remained after controlling for changes in depressive symptoms. No significant differences were found in subjective cognitive function, processing speed, or attention over the 2-week follow-up. The results suggest N2O may have a pro-cognitive effect on executive function independent of mood improvement.

DOI: 10.1016/j.psychres.2023.115326 Full text Treatment-resistant depression Cognitive deficits Executive function Nitrous oxide +1

Efficacy and safety of nitrous oxide for patients with treatment-resistant depression, a randomized controlled trial.

Psychiatry research November 1, 2022 Danfeng Yan, Bangshan Liu, Xiyu Wei et al.

A single one-hour inhalation of 50% nitrous oxide (N2O) mixed with oxygen rapidly alleviated depression in patients with treatment-resistant depression in China, but the effect lasted no more than one week. In a double-blind, placebo-controlled trial, 44 patients were randomized to receive either 50% N2O or a placebo mixture. Depression scores on the Hamilton Depression Rating Scale were significantly lower in the N2O group at two hours and 24 hours after treatment, but no significant difference remained at one week or two weeks. Patients receiving N2O reported more adverse events, all of which resolved within 24 hours, and no serious adverse events occurred.

DOI: 10.1016/j.psychres.2022.114867 Full text Treatment-resistant depression Nitrous oxide Randomized controlled trial