Nabilone Impairs Spatial and Verbal Working Memory in Healthy Volunteers.
Cannabis and cannabinoid research February 1, 2024 Faiz M Kassim, Sophie Tod, Jennifer Rodger et al.
A single low oral dose of the synthetic cannabinoid nabilone (1-2 mg) impaired both verbal and spatial working memory in healthy adults, with a stronger effect in people who used cannabis less frequently. Spatial working memory was more affected than verbal working memory. The drug did not significantly change psychosis-like experiences (schizotypy scores). However, higher schizotypy scores were linked to worse working memory under placebo, and more frequent cannabis use was associated with better overall working memory across drug conditions, suggesting tolerance to the memory-impairing effects of cannabinoids.