21 Psychedelic treatment of functional neurological disorder – a systematic review
Journal of Neurology Neurosurgery & Psychiatry July 20, 2020 Matthew Butler, Mathieu Seynaeve, Timothy R. Nicholson et al.
Functional neurological disorder (FND) causes significant disability, yet treatment options are limited. A systematic review of nine studies from 1954–1967 involving 26 patients found that psychedelics, primarily LSD (25–2,000 mcg) and psilocybin (3–15 mg), were used alongside psychotherapy. After treatment, 69% of patients showed at least some recovery, and 23% fully recovered. Adverse events were mild and transient. Although the studies were low quality and lacked control groups, the degree of improvement suggests psychedelics may be a promising treatment for FND, warranting modern research.