Chromosome Studies on Patients (in Vivo) and Cells (in Vitro) Treated with Lysergic Acid Diethylamide
New England Journal of Medicine April 23, 1970 Margaret J. Corey, J. C. Andrews, M.Josephine McLeod et al. 25 citations
In a prospective study of 10 patients given d-lysergic acid diethylamide 25, the frequency of chromosome breakage did not differ between samples taken immediately before and 24 hours after treatment. Among 11 patients treated over periods from 24 hours to eight years before sampling, the frequency of chromosomal breaks was similar to that in untreated controls. In an in vitro study, adding 1 μg per milliliter of the drug during the last 24 hours of culture increased chromosomal breakage in replicate cultures from each of 10 subjects. The authors conclude there is no cytogenetic evidence that therapeutic use of d-lysergic acid diethylamide 25 produces chromosomal damage, while aberrations after illicit use remain unexplained.