Pathologic gamblers show higher novelty seeking and self-transcendence, and lower self-directedness and cooperativeness, compared with both non-pathologic gamblers and control subjects. A positive correlation exists between gambling severity and both novelty seeking and self-transcendence scores. Pathologic gamblers with a family history of gambling have even higher novelty seeking. These personality dimensions may help identify individuals at risk for problem gambling and inform treatment approaches.
LSD induces gene expression patterns that oppose the transcriptional signatures of brain aging and dementia. By comparing chronic LSD treatment in rodents with age- and dementia-related gene expression changes in the human prefrontal cortex, the authors show that LSD's effects are strongly anti-correlated with these disease programs, a reversal specific compared to other pharmacological perturbations and reproducible across datasets and species. LSD also counteracts amyloid-β-induced structural and molecular alterations in primary cortical neurons, linking transcriptomic opposition to functional rescue under neurodegenerative stress. These findings suggest LSD modulates molecular and cellular pathways associated with brain aging and neurodegeneration.