The many faces of psilocybin-related psychosis: A case series
Psychiatry Research Case Reports December 7, 2024 Yumin Kim, Rachel Bigley, Aubrey DeVinney et al. 4 citations
Three cases from a dual diagnosis inpatient psychiatry unit in 2023 illustrate distinct adverse effects of psilocybin use. Intermittent use led to prolonged psychosis requiring higher and longer neuroleptic treatment; frequent short-term use culminated in paranoia and a serious suicide attempt treated with neuroleptics; long-term microdosing preceded mania-like symptoms—grandiosity, irritability, physical aggression—that resolved after stopping psilocybin. As psilocybin becomes more accepted and prevalent, clinicians lack guidelines for managing its complications. This case series describes varied presentations, management strategies, and treatment responses to provide insight into this unknown territory.