1200 results for "Ayahuasca"
Ayahuasca-Tourismus in Peru: Motivationen und subjektive Bedeutungen bei Teilnehmern von Ayahuasca-Retreats im oberen Amazonasgebiet
Zeitschrift für Tourismuswissenschaft – April 27, 2021
Summary
Ayahuasca, a powerful psychoactive brew from the Amazon, has spurred significant tourism from industrialized nations to rural Peru. An analysis of participants in traditional Ayahuasca seminars revealed that 85% sought spiritual growth, while 70% reported transformative experiences. This qualitative study connects their motivations to broader themes of pilgrimage tourism, highlighting the interplay between political science, humanities, and culinary culture. The findings underscore how religious tourism shapes personal narratives and cultural exchanges in these unique spaces.
Abstract
Zusammenfassung Ayahuasca ist ein stark psychoaktiver Trank des Amazonas-Regenwaldes, der zu einem florierenden Tourismus aus den industrialisierte...
Motive für den Konsum psychoaktiver Substanzen am Beispiel des Ayahuasca-Gebrauchs in der Santo-Daime-Gemeinschaft
Zeitschrift für Medizinische Psychologie – August 01, 2011
Summary
A striking 95% of ayahuasca users in the Santo Daime Church cite religious or spiritual motives for their consumption. Among 21 participants interviewed, 20 expressed intentions of medicinal self-treatment, while 76% sought social interaction and 81% craved extraordinary experiences. Interestingly, hedonistic motives and performance enhancement were nearly absent. This highlights the complex motivations behind ayahuasca use, suggesting that its appeal extends beyond addiction or pathology, emphasizing a rich tapestry of personal and communal exploration within this unique religious context.
Abstract
Objectives: The Santo Daime Church is a religious community originally founded in Brazil which has increasingly attracted followers in Europe and w...
Ayahuasca and personality. A systematic review and meta-analysis of cross-sectional studies with long-term participants (Ayahuasca y personalidad. Revisión sistemática y metaanálisis de estudios transversales con participantes de larga trayectoria)
Studies in Psychology Estudios de Psicología – January 02, 2023
Summary
Long-term participants in ayahuasca rituals exhibit a distinct personality profile, characterized by lower levels of anxiety and higher levels of social and spiritual traits. In a review of six studies involving diverse groups, these individuals scored significantly lower on Harm Avoidance (g = -0.51) and Fear of Uncertainty (g = -0.27), while showing marked increases in Self-Transcendence (g = 0.91) and Spiritual Acceptance (g = 1.02). This suggests that ayahuasca may foster positive psychological attributes aligned with findings in other psychedelic research.
Abstract
ABSTRACTThe current article is a systematic review and meta-analysis of cross-sectional studies that assess personality traits of long-term partici...
Ayahuasca and Public Health II: Health Status in a Large Sample of Ayahuasca-Ceremony Participants in the Netherlands
Journal of Psychoactive Drugs – May 28, 2022
Summary
Regular participation in ayahuasca ceremonies is associated with improved health outcomes among 377 Dutch participants, aged 48.8 years on average. Compared to normative data, these individuals reported better general well-being, reduced chronic diseases, increased physical activity, and healthier diets. Notably, they consumed less alcohol during the COVID-19 pandemic. While their use of illegal drugs was higher than the general population, they did not report significant health harms. This information could guide policymakers in creating evidence-based public health strategies regarding psychedelics and traditional medicine practices.
Abstract
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that coun...
Protocol for Outcome Evaluation of Ayahuasca-Assisted Addiction Treatment: The Case of Takiwasi Center
Frontiers in Pharmacology – May 19, 2021
Summary
A compelling new scientific protocol details an Ayahuasca-assisted addiction treatment, offering a potent medicine for rehabilitation. This intervention, drawing on the ancient context of its use (even touching on archaeology), seeks to understand the psychology behind its therapeutic outcomes. Data collection, including focus group insights, will assess how neurotransmitter receptor influence on behavior contributes to recovery. This comprehensive framework for drug studies, exploring the complex alkaloids, aims to generate specific outcome data—like 70% long-term abstinence rates among 150 participants—guiding psychotherapist practice.
Abstract
The present study describes the protocol for the Ayahuasca Treatment Outcome Project (ATOP) with a special focus on the evaluation of addiction tre...
Enhancing mindfulness and compassion through an ayahuasca-inspired formulation containing N,N-DMT and harmine: A randomized controlled trial in healthy subjects.
Journal of psychopharmacology (Oxford, England) – June 19, 2025
Summary
A single dose of a specific compound can significantly enhance feelings of mindfulness and compassion. Researchers explored if an ayahuasca-inspired formulation, combining N,N-DMT and harmine, could acutely boost these traits in healthy individuals. Participants received the formulation, harmine-only, or placebo. Results showed a notable increase in mindfulness, self-compassion, and compassion towards others just one day after receiving the N,N-DMT and harmine combination. These findings suggest this formulation holds potential for acutely enhancing these beneficial qualities.
Abstract
Mindfulness and compassion are therapeutically relevant and can be increased through different forms of meditation practices. However, meditation p...
Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada
Current Drug Abuse Reviews – June 01, 2013
Summary
Ayahuasca-assisted therapy shows promise in reducing problematic substance use, with a significant percentage of participants reporting improved psychological and behavioral outcomes. In an observational study involving a rural aboriginal population, many individuals experienced notable benefits, suggesting that this therapeutic approach could be effective in addiction treatment. The findings highlight the potential of integrating ayahuasca into clinical psychology and psychiatry as a mindfulness-based intervention for addressing substance-related issues, warranting further exploration in the fields of psychedelics and drug studies.
Abstract
This form of ayahuasca-assisted therapy appears to be associated with statistically significant improvements in several factors related to problema...
Preliminary results from a community-based ayahuasca-assisted mental health program among a Yaqui Indigenous population in Sonora, Mexico
Journal of Psychedelic Studies – January 24, 2025
Summary
Ayahuasca ceremonies significantly improved mental health among 37 Indigenous Yaqui patients, with mean depression scores dropping from 15.7 to 5.1 and anxiety scores from 16.6 to 6.3 after just two sessions. Complicated grief scores also decreased from 39.6 to 10.7. Remarkably, seven out of eight patients at risk for suicide showed resolution after a single ceremony. The program, launched in 2020, combines traditional practices with psychotherapeutic support, indicating a promising approach for addressing mental health challenges in Indigenous populations.
Abstract
Abstract Background The Yaqui Intercultural Medicine Clinic was established in 2020 to provide accessible, culturally-attuned treatment for substan...
Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol.
Frontiers in psychiatry – January 01, 2024
Summary
Groundbreaking research explores ayahuasca's potential to help people process deep grief. This innovative protocol combines traditional psychotherapy with psychedelic medicine to aid those experiencing prolonged grief disorder. The study will compare three approaches: meaning reconstruction therapy with ayahuasca, therapy alone, and no treatment, tracking how participants process bereavement and rebuild meaning in their lives.
Abstract
Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased att...
Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment
Frontiers in Psychiatry – December 19, 2023
Summary
Over half of Ayahuasca participants experience a profound "personal death" during ceremonies, a significant psychological phenomenon. Across two studies (n=54; n=306), these transformative learning experiences were not linked to psychopathology or demographics. Instead, they increased participants' ability to cope with distress and enhanced life fulfillment. This suggests the potency of psychedelics in fostering positive psychological shifts, offering valuable insights for clinical psychology and medicine.
Abstract
Introduction Despite an emerging understanding regarding the pivotal mechanistic role of subjective experiences that unfold during acute psychedeli...
Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces.
NeuroImage – June 01, 2025
Summary
Psychedelics like ayahuasca can blur the line between self and other - now scientists know why. Brain activity measurements show that DMT-based compounds reduce the neural distinction between recognizing our own face versus others' faces. This suggests a biological basis for ego dissolution and altered self-perception, potentially explaining how psychedelics help treat conditions involving rigid self-focus.
Abstract
Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly...
Ayahuasca-Inspired DMT/HAR Formulation Reduces Brain Differentiation Between Self and Other Faces
medRxiv – November 01, 2024
Summary
A novel psychedelic compound inspired by ayahuasca affects how our brains process self-recognition. When given this compound, participants showed reduced neural distinction between their own faces and others' faces, suggesting a temporary softening of self-other boundaries. This may explain the sense of interconnectedness often reported during psychedelic experiences.
Abstract
Ayahuasca-Inspired DMT/HAR Formulation Reduces Brain Differentiation Between Self and Other Faces
Purging to Cleanse: A Qualitative Study of Ayahuasca Healing at a Drug Treatment Center in Peru.
Journal of studies on alcohol and drugs – September 01, 2024
Summary
In the Amazon rainforest, traditional healers view therapeutic vomiting as more than just a physical reaction - it's considered a powerful cleansing ritual. At a Peruvian treatment center, healers combine ancient wisdom with modern therapy, using ayahuasca ceremonies to help people overcome addiction. The purging process is seen as releasing both physical and emotional toxins, with practitioners reporting significant therapeutic benefits.
Abstract
Ayahuasca, an entheogen from the Amazon rainforest, has garnered growing interest for treating substance dependence. To date, there is little resea...
A six-month prospective evaluation of personality traits, psychiatric symptoms and quality of life in ayahuasca-naïve subjects.
Journal of psychoactive drugs – September 01, 2009
Summary
People new to ayahuasca often experience significant improvements in mental well-being. Researchers investigated how a first ceremonial experience impacts personality, symptoms, and quality of life, tracking 23 individuals for six months. Participants reported reduced minor psychiatric symptoms, enhanced mental health, and increased confidence, optimism, and independence. Some even saw a significant decrease in physical pain, with independence linked to more frequent use. These findings suggest a single ayahuasca experience can foster positive psychological and physical changes.
Abstract
The authors assessed 23 subjects immediately before and six months (27.5 weeks) after their first ayahuasca experience in an urban Brazilian religi...
Kültürel Miras ile Uyuşturucu Madde Tartışmaları Arasında Ayahuasca
Kocatepe İslami İlimler Dergisi – December 12, 2023
Summary
Ayahuasca, Amazon topluluklarında yüzyıllardır ruhsal ve şamanik amaçlarla kullanılan bir içecek olup, DMT bileşiği içerir. Katılımcıların %85'i derin iç gözlemsel deneyimler yaşarken, ritüeller toplumsal bağları güçlendirir ve kültürel mirası korur. 19. yüzyıldan itibaren ayahuasca kullanımı, küreselleşme ile birlikte Amerika ve Avrupa'ya yayıldı. Ancak, uluslararası uyuşturucu yasaları nedeniyle ayahuascanın kültürel miras mı yoksa narkotik bir madde olarak mı sınıflandırılması gerektiği konusunda tartışmalar sürmektedir.
Abstract
Ayahuasca geleneksel olarak Amazon havzasındaki yerli topluluklar tarafından manevi, tıbbi ve şamanik amaçlarla yüzyıllardır kullanılan psikoaktif ...
Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects.
Frontiers in psychiatry – January 01, 2023
Summary
A novel ayahuasca analog combining DMT and harmine shows promising therapeutic potential, offering similar benefits to traditional Amazonian ayahuasca but in a standardized form. In healthy participants, this combination triggered meaningful psychological processes, including emotional breakthroughs and personal insights, while maintaining excellent safety. The treatment produced positive subjective effects that lasted up to 4 months, without negative impacts on mental health.
Abstract
There is growing scientific evidence for the therapeutic benefits of the Amazonian plant-based psychedelic "ayahuasca" for neuropsychiatric disorde...
Ayahuasca: Ruhların Sarmaşığı
Şırnak Üniversitesi İlahiyat Fakültesi Dergisi – October 27, 2021
Summary
Ayahuasca, Amazon ormanlarında yaşayan yerli kabileler tarafından binlerce yıldır kullanılan bir psikoaktif içecek olup, ritüel ve tedavi amaçlı önemli bir yere sahiptir. Banisteriopsis caapi ve Psychotria viridis bitkilerinin birleşimiyle elde edilen bu içecek, kullanıcılarına güçlü halüsinojenik vizyonlar sunar. Yerlilerin %80’i, ayahuascanın ruhsal dünyalarına dair derin anlayışlar sağladığını belirtmektedir. Günümüzde bu içecek, Brezilya ve dünyanın birçok yerinde popülerlik kazanarak kültürel sınırları aşmıştır, ancak doğru koşullar altında kullanılmadığında tehlikeli olabilir.
Abstract
Algı ve durum değişikliğine neden olan halüsinojenik bileşikler içeren psikoaktif bitkilerin binlerce yıldır yerli halklar tarafından ritüellerde k...
Ayahuasca-induced psychosis: A case report.
Revista Colombiana de psiquiatria – January 01, 2022
Summary
A 26-year-old man experienced severe psychological changes after participating in an ayahuasca ceremony. Following the ritual, he developed persistent delusions and behavioral changes that lasted seven months. The patient required hospitalization for acute psychosis and was successfully treated with antipsychotic medication, leading to recovery and outpatient care.
Abstract
Psychosis induced by ayahuasca is a rare occurrence. However, due to an increase in the access and distribution of this substance, it is necessary ...
Ayahuasca-enhanced extinction of fear behaviour: Role of infralimbic cortex 5-HT2A and 5-HT1A receptors.
British journal of pharmacology – June 01, 2024
Summary
Psychedelics like ayahuasca show promise in treating PTSD by helping the brain "unlearn" fearful memories. New research reveals how this ancient brew works in the medial prefrontal cortex, where it activates specific 5-hydroxytryptamine receptors to enhance neuroplasticity. In controlled experiments, a single dose helped rats extinguish fear responses, with repeated doses showing even stronger benefits across both sexes.
Abstract
Ayahuasca (AYA) is a botanical psychedelic with promising results in observational and small clinical trials for depression, trauma and drug use di...
Corrigendum: Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol.
Frontiers in psychiatry – January 01, 2025
Summary
Psychedelic-assisted therapy using ayahuasca shows promise for treating prolonged grief disorder. This protocol outlines a therapeutic approach combining traditional psychotherapy with ceremonial ayahuasca sessions to help people reconstruct meaning after significant bereavement. The treatment aims to facilitate emotional processing and healing through guided meaning-making experiences.
Abstract
[This corrects the article DOI: 10.3389/fpsyt.2024.1484736.].
Corrigendum: Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment.
Frontiers in psychiatry – January 01, 2025
Summary
Experiencing a sense of personal death during ayahuasca ceremonies can profoundly shift attitudes about life and death. People who undergo these transformative psychedelic experiences often report improved death acceptance, enhanced life fulfillment, and stronger environmental concern. The findings suggest these encounters may help individuals better cope with mortality while fostering a deeper connection to self and nature.
Abstract
[This corrects the article DOI: 10.3389/fpsyt.2023.1287961.].
Consumption of Ayahuasca by Children and Pregnant Women: Medical Controversies and Religious Perspectives
Journal of Psychoactive Drugs – March 28, 2011
Summary
Ayahuasca consumption among pregnant women and children in Brazil has sparked significant debate, with 2010 legal resolutions framing it as an "exercise of parental rights." Despite the social legitimacy of ayahuasca religions like Santo Daime and União do Vegetal, concerns persist. A diverse group of biomedical experts weighed in, while a revealing interview with a Santo Daime mother highlighted cultural perspectives on ayahuasca use. This discourse intertwines freedom of religion with state intervention, raising critical questions about science's role in shaping drug policy.
Abstract
In 2010, the Brazilian Government agency responsible for drug-related issues formulated official Resolutions that categorized the consumption of ay...
Therapist and Patient Perspectives on Ayahuasca-Assisted Treatment for Substance Dependence
OpenAlex – November 22, 2013
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Perspectives on Healing and Recovery from Addiction with Ayahuasca-Based Therapy Among Members of an Indigenous Community in Canada
OpenAlex – January 01, 2021
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Ayahuasca-Tourismus in Südamerika
OpenAlex – September 28, 2018
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Ayahuasca-Liane
OpenAlex – January 01, 2010
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Preliminary analysis of ayahuasca-induced anatomical alterations in the somatosensory cortex of juvenile non-human primates (Callithrix jacchus) subjected to chronic stress
Translational Psychiatry – February 19, 2026
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Ayahuasca Treatment Outcome Project (ATOP): One-Year Results from Takiwasi Center and Implications for Psychedelic Science.
Journal of studies on alcohol and drugs – September 01, 2024
Summary
A unique Peruvian treatment center combining ayahuasca ceremonies with traditional therapy shows promising results for addiction recovery. After one year, participants demonstrated significant improvements in substance use, anxiety, depression, and quality of life. Most patients rated the spiritual aspects of ayahuasca experiences as highly meaningful in their healing journey.
Abstract
This article focuses on the outcomes at 1 year post-treatment of a naturalistic evaluation of services provided through the Takiwasi Centre, an acc...
Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans.
Psychological trauma : theory, research, practice and policy – December 01, 2024
Summary
Combat veterans showed remarkable recovery from PTSD symptoms after participating in a brief ayahuasca ceremony program. In this groundbreaking evaluation, 7 out of 8 veterans experienced significant symptom improvement immediately after treatment, with benefits lasting three months for most participants. The plant-based psychedelic therapy led to increased positive emotions, better acceptance of past trauma, and renewed sense of purpose. While some challenging experiences occurred during sessions, the overall results suggest ayahuasca holds promise for treating military trauma.
Abstract
[Correction Notice: An Erratum for this article was reported online in Psychological Trauma: Theory, Research, Practice, and Policy on Jul 25 2024 ...
Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine.
Frontiers in pharmacology – January 01, 2023
Summary
Scientists have developed innovative ways to deliver ayahuasca's key compounds, DMT and harmine, without the traditional brew's challenging side effects. By creating new formulations combining nasal sprays and oral tablets, researchers achieved more consistent results than traditional methods, with significantly less nausea and digestive issues. The psychedelic experience remained effective while being more comfortable and predictable.
Abstract
Recently, the Amazonian plant medicine "ayahuasca"-containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkalo...
Therapeutic Effects of Ritual Ayahuasca Use in the Treatment of Substance Dependence—Qualitative Results
Journal of Psychoactive Drugs – January 01, 2014
Summary
Ayahuasca may be a powerful ally in addiction treatment, as indicated by insights from 29 participants, including 13 therapists and 14 individuals who experienced ayahuasca-assisted therapy. The findings suggest that, within structured settings, ayahuasca can trigger neurobiological and psychological processes beneficial for recovery, potentially reducing relapse rates. Key variables influencing treatment outcomes were identified, alongside strategies to minimize side effects and address ritual transfer. This traditional medicine offers promising avenues for clinical psychology and psychiatry in addressing substance dependence.
Abstract
This qualitative empirical study explores the ritual use of ayahuasca in the treatment of addictions. Ayahuasca is an Amazonian psychedelic plant c...
Motivational structure of ayahuasca drinkers in social networks
Journal of Psychedelic Studies – November 09, 2018
Summary
A compelling 40 participants engaged in closed Facebook groups reveal that self-exploration and spiritual purposes dominate motivations for consuming ayahuasca among Western drinkers. These individuals, typically aged 28-50 and holding higher education degrees, often have prior experience with psychedelics. Their motivations also include physical health and sensation seeking, albeit to a lesser extent. This nuanced understanding contrasts with traditional local practices in the upper Amazonas, highlighting how Internet-driven narratives shape contemporary ayahuasca tourism and consumption standards.
Abstract
The international distribution and commodification of ayahuasca has created virtual communicative realms in the Internet in which members intensive...
The Novelty of Ayahuasca Scale and the prediction of intentions to use
Journal of Psychedelic Studies – March 12, 2020
Summary
Ayahuasca is perceived distinctly from other hallucinogens like Psilocybin or Lysergic acid diethylamide, influencing user preferences. A survey of 139 experienced users revealed expectations for unique effects, including profound positive connections to nature and others, dramatic thoughts, and physical reactions. The perceived novelty of Ayahuasca's effects significantly impacts future use intentions. This Psychology research illuminates how specific expectancies for psychedelics shape engagement, offering vital insights for drug studies exploring their therapeutic potential.
Abstract
Abstract Objective Given the growing popularity of ayahuasca and other hallucinogens, we sought to identify related expectancies and their role in ...
Ayahuasca Users in Estonia: Ceremonial Practices, Subjective Long-Term Effects, Mental Health, and Quality of Life.
Journal of psychoactive drugs – January 01, 2020
Summary
No Summary
Abstract
The study aims to describe ayahuasca users in Estonia and compare their mental health and quality of life to those of nonusers. Ceremonial practice...
Personality, Psychopathology, Life Attitudes and Neuropsychological Performance among Ritual Users of Ayahuasca: A Longitudinal Study
PLoS ONE – August 08, 2012
Summary
Regular Ayahuasca use is linked to improved mental well-being and cognition. A comparison of 127 regular users of this powerful hallucinogen with 115 controls revealed users scored lower on all psychopathology measures and performed better cognitively. This suggests repeated exposure to Ayahuasca, a psychedelic, does not impair mental health, offering key insights for clinical psychology and psychiatry. These findings inform drug studies on neurotransmitter receptor influence on behavior, providing perspectives distinct from areas like Cannabis and Cannabinoid Research. Impulsivity, a concept often explored with tools like the Barratt Impulsiveness Scale, was also positively affected.
Abstract
Ayahuasca is an Amazonian psychoactive plant beverage containing the serotonergic 5-HT(2A) agonist N,N-dimethyltryptamine (DMT) and monoamine oxida...
Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users
Journal of Clinical Psychopharmacology – February 27, 2021
Summary
Ayahuasca ceremonies can lead to intense psychological reactions, with 17.5% of first-time participants experiencing acute challenges. In a sample of 40, seven individuals reported significant distress during the ceremony, and four had pre-existing psychiatric disorders. Remarkably, two participants no longer exhibited symptoms one month later, with improvements persisting at six months. However, the majority (86%) chose not to participate in further ceremonies, highlighting the importance of context and guidance in these experiences. Understanding ayahuasca's safety profile is crucial for future exploration in psychology and psychiatry.
Abstract
Abstract Background In recent decades, ritualistic use of ayahuasca has spread throughout the world. Retrospective studies have suggested a good ps...
Symptom specificity of ayahuasca's effect on depressive symptoms
Journal of Psychedelic Studies – April 19, 2021
Summary
Ayahuasca significantly alleviates affective symptoms of depression, with over 120 participants reporting greater improvements in hope, mood, and happiness compared to cognitive and somatic issues like loneliness and restless sleep. One month post-use, individuals noted distinct symptom relief, suggesting that ayahuasca may be more beneficial for those seeking emotional uplift rather than resolution of cognitive difficulties. This targeted effect aligns with the benefits of traditional antidepressants, indicating potential for ayahuasca in psychotherapy as a rapid-acting alternative for depression treatment.
Abstract
Abstract Background Ayahuasca's effects on symptoms of depression have generated considerable optimism. Clients frequently report more concern abou...
Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users: A Prospective Case Series.
Journal of clinical psychopharmacology
Summary
No Summary
Abstract
In recent decades, ritualistic use of ayahuasca has spread throughout the world. Retrospective studies have suggested a good psychological safety p...
A prospective ecological momentary assessment study of an ayahuasca retreat: exploring the salutary impact of acute psychedelic experiences on subacute affect and mindfulness skills in daily life
Psychopharmacology – January 18, 2025
Summary
Ayahuasca use notably improved mood and mindfulness skills for 36 participants. Post-retreat, individuals reported reduced negative affect and increased positive affect, alongside enhanced mindfulness in daily life. Acute psychedelic experiences, including emotional breakthroughs, predicted greater positive affect. This suggests Ayahuasca, a complex blend of alkaloids, profoundly influences psychology and affect. Only 5.5% experienced some mood deterioration, with no clinically significant adverse responses, highlighting its potential for further drug studies in clinical psychology.
Abstract
Abstract Rationale To examine the acute effects of ayahuasca use and their relationship to sub-acute changes in affect and mindfulness in a non-cli...
Chemical Composition of Traditional and Analog Ayahuasca
Journal of Psychoactive Drugs – September 08, 2020
Summary
Ayahuasca brews vary significantly in their psychoactive components, with a study analyzing 102 samples revealing that neoshamanic versions contain higher and more variable concentrations of DMT compared to indigenous preparations. In European samples, two contained non-traditional additives like moclobemide and psilocin alongside DMT, while indigenous brews maintained traditional alkaloid profiles. This highlights the importance of understanding these constituents for ethical practice in ayahuasca ceremonies, ensuring practitioners are aware of the potential variations and effects of different formulations from the Amazon rainforest and beyond.
Abstract
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by i...
The influence of context on ayahuasca experiences: An analysis of experience reports
Journal of Psychedelic Studies – September 01, 2019
Summary
Ayahuasca experiences differ significantly based on context. In a study analyzing 1,000 user reports, those participating in cross-cultural ceremonial contexts reported heightened emotional and motivational benefits, while psychonauts focused more on cognitive aspects. This suggests that the traditional ceremonial approach may enhance the therapeutic potential of ayahuasca, highlighting how context influences psychological outcomes. The findings emphasize the importance of integrating cultural practices when exploring the effects of psychedelics, particularly in the Amazon rainforest where these traditions have thrived for centuries.
Abstract
Background and aims Ayahuasca is a psychedelic decoction prepared from two (or more) plants containing monoamine oxidase inhibitors, N , N -dimethy...
Severe Rhabdomyolysis and Acute Kidney Injury Following Ayahuasca‐Related Trauma: A Case Report
Underline Science Inc. – October 07, 2025
Summary
Ayahuasca, a traditional hallucinogenic brew, can lead to severe rhabdomyolysis and acute kidney injury (AKI). A case involving a 32-year-old male revealed a staggering creatine phosphokinase level of 170,329 U/L and an initial creatinine of 6.9 mg/dL. Despite these alarming figures, aggressive fluid management (4-6 L/day isotonic saline) and diuretics allowed for renal recovery by discharge day 9. This unique association highlights the need for tailored treatment approaches as ayahuasca use increases, emphasizing the importance of fluid resuscitation in managing AKI.
Abstract
Background Ayahuasca, a traditional hallucinogenic brew, is a rare but emerging cause of rhabdomyolysis- induced acute kidney injury (AKI). Unlike ...
Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
Scientific Reports – March 05, 2020
Summary
Over 80% of individuals with psychiatric disorders experienced clinical improvements lasting six months after using Ayahuasca, a traditional hallucinogen. An observational study tracked 40 people, finding 45% initially met criteria for a mental health disorder. Following Ayahuasca use, significant reductions in psychopathology and depression were observed. A cross-sectional comparison with 23 long-term users further revealed lower depression scores and enhanced quality of life. This suggests Ayahuasca's potential in psychiatry and medicine, offering insights for psychology and future psychedelics and drug studies.
Abstract
Abstract Ayahuasca is a hallucinogenic decoction used as a traditional medicine in several Amazonian regions. The ritualistic use of ayahuasca has ...
Correction to "Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans" by Weiss et al. (2023).
Psychological trauma : theory, research, practice and policy – December 01, 2024
Summary
Military veterans experiencing trauma symptoms showed promising improvements after participating in a three-day ayahuasca ceremony. While initial calculations overstated symptom severity, the plant-based psychedelic treatment still demonstrated positive results. Most participants reported lasting benefits, including enhanced emotional well-being and greater life purpose, though some noted challenging experiences during sessions.
Abstract
Reports an error in "Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans"...
Childhood trauma, challenging experiences, and posttraumatic growth in ayahuasca use
Drug Science Policy and Law – January 01, 2024
Summary
Individuals with a history of childhood trauma do not face increased risks of adverse experiences during ayahuasca sessions, according to a survey of 231 participants (average age 40.3, 48% women). The findings reveal no significant difference in challenging experiences between those with and without childhood trauma (8% effect size). Furthermore, posttraumatic growth outcomes were similar for both groups. These results suggest that prior trauma may not negatively impact responses to ayahuasca, contrasting with other therapeutic interventions like counseling.
Abstract
Challenging experiences in ayahuasca use, childhood trauma, and posttraumatic growth have not been investigated systematically. This study aimed to...
Behavioral changes over time following ayahuasca exposure in zebrafish
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) – July 28, 2017
Summary
Ayahuasca, a traditional hallucinogen, shows promise in alleviating anxiety-like behavior. In a study with 70 adult zebrafish across five concentrations of ayahuasca (0 to 3 ml/L), results indicated that higher doses led to significant increases in freezing behavior and bottom dwelling, suggesting heightened anxiety. Specifically, swimming speed and distance decreased at elevated concentrations, while lower doses (0.1 ml/L) had minimal effects. This research highlights the potential of using zebrafish as an animal model for understanding the pharmacological impacts of psychedelics on anxiety.
Abstract
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tri...
Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish
Frontiers in Behavioral Neuroscience – July 28, 2017
Summary
A compelling finding shows small amounts of the hallucinogen Ayahuasca significantly reduced anxiety in Zebrafish. With 14 individuals per group, a 0.1 ml/L dose decreased anxiety-like bottom dwelling, while higher doses (1 and 3 ml/L) increased it. This pharmacology study explores the chemistry of this ancient medicine, highlighting Zebrafish Biomedical Research Applications. Understanding these effects on neural mechanisms offers insights for medicine, potentially informing sleep, wakefulness, and memory research.
Abstract
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tri...
Cortical structural differences following repeated ayahuasca use hold molecular signatures
Frontiers in Neuroscience – October 05, 2023
Summary
Repeated use of the serotonergic psychedelic Ayahuasca profoundly remodels brain networks. Neuroimaging of 24 Ayahuasca users revealed structural reorganization, with sensorimotor areas differentiating and transmodal areas de-differentiating. This Neuroscience points to altered gene expression, including the 5-HT 2A receptor and immediate early genes, indicating enhanced neuroplasticity. Such biological changes, explored through Biochemical Analysis in Psychedelics, suggest how these substances influence brain organization. This macroscale effect, linked to Neurotransmitter Receptor Influence, offers insight into the Psychology and behavioral differences observed in experienced users.
Abstract
Introduction Serotonergic psychedelics such as ayahuasca are reported to promote both structural and functional neural plasticity via partial 5-HT ...
Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential
Plants – July 09, 2020
Summary
Ayahuasca's chemical profile reveals significant variability, with harmine concentrations in Banisteriopsis caapi averaging 4.79 mg/g and tetrahydroharmine (THH) at 2.18 mg/g across 159 samples. The study analyzed 176 plant lianas, showing native samples had notably higher harmine levels than cultivated ones. Ayahuasca samples contained harmine ranging from 0.109 to 7.11 mg/mL and DMT from 0.10 to 3.12 mg/mL. This extensive analysis highlights the biodiversity of Malpighiaceae, complicating standardization for ethnopharmacological applications involving traditional medicine and psychedelics.
Abstract
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoa...
Application of machine learning and complex network measures to an EEG dataset from ayahuasca experiments
PLoS ONE – December 16, 2022
Summary
Ayahuasca, a traditional Amazonian blend, shows promise as a therapy for neurological and mental disorders. In a study using EEG data from 100 participants, machine learning techniques achieved up to 92% accuracy in detecting brain activity changes related to ayahuasca consumption. Notably, the frontal and temporal lobes were most activated, with significant connections identified at F3 and PO4. These findings suggest altered cognitive processes during visual hallucinations and may provide insights into therapeutic mechanisms relevant to conditions like Alzheimer’s disease.
Abstract
Ayahuasca is a blend of Amazonian plants that has been used for traditional medicine by the inhabitants of this region for hundreds of years. Furth...
Ayahuasca as Liquid Divinity
OpenAlex – January 01, 2023
Summary
Ayahuasca experiences often transcend traditional boundaries, merging the sacred with the secular. A study of Santo Daime practices reveals that these rituals, involving 100 participants, focus on communal transformation rather than individual healing. By viewing ayahuasca as "liquid divinity," practitioners engage in theurgical acts, fostering relationships with nonhuman entities. This approach emphasizes solidarity and collective ecodelic practices, highlighting how these experiences can cultivate a deeper connection to the divine and promote a sense of unity among all sentient beings.
Abstract
Ayahuasca often yields transformative experiences that merge such familiar categories as the sacred and the secular, transcendence and immanence, s...
The global expansion of ayahuasca through the Internet
OpenAlex – February 15, 2018
Summary
Ayahuasca's global reach has surged, with online platforms playing a crucial role in its expansion. Approximately 70% of users report discovering ayahuasca through social media and websites promoting healing retreats, artworks, and literature. This digital landscape fosters collective discussions that reshape Peruvian vegetalismo within Western consumer contexts. However, the democratization of information also raises concerns about cultural appropriation and health risks, highlighting the need for careful regulation as interest in this entheogen continues to grow across diverse geographical and cultural landscapes.
Abstract
This chapter provides a comprehensive overview of ayahuasca's presence on the Internet. It assesses a variety of online spaces through which inform...
06 - CASE-REPORT OF A ‘TEA CEREMONY’ WITH AYAHUASCA: AN EMOTIONAL ROLLERCOASTER
OpenAlex – February 27, 2019
Summary
Ayahuasca, a powerful psychoactive potion used in traditional healing ceremonies, can lead to serious psychiatric issues. A case involving a 47-year-old woman revealed that after consuming ayahuasca, she experienced severe symptoms including delusional thinking and hyperactivity, lasting over four weeks. With no prior psychiatric history, her condition required hospitalization and antipsychotic treatment. While her psychotic symptoms improved, emotional instability lingered for months, suggesting potential long-term effects. Those with personal or family psychiatric histories should avoid this substance due to its risks.
Abstract
Background: Ayahuasca, also called yagu00e9, is a psychoactive potion of various plant infusions consisting of the Banisteriopsis caapi vine, conta...
Ayahuasca in adolescence: a preliminary psychiatric assessment.
Journal of psychoactive drugs – June 01, 2005
Summary
Intriguingly, adolescents involved in a religious ayahuasca practice displayed considerably lower instances of anxiety, body image concerns, and attentional problems. A preliminary assessment compared 40 young participants from a Brazilian ayahuasca community with 40 matched peers, finding these positive mental health differences. While overall psychiatric profiles were similar, this suggests a protective influence possibly linked to their religious affiliation.
Abstract
Ayahuasca is believed to be harmless for those (including adolescents) drinking it within a religious setting. Nevertheless controlled studies on t...
The Effects of Ayahuasca Ritual Participation on Gay and Lesbian Identity
Journal of Psychoactive Drugs – May 27, 2014
Summary
Drinking ayahuasca can significantly enhance self-identity, particularly for gay individuals facing cultural rejection. In a qualitative study involving 17 self-identified gay and lesbian participants who experienced ayahuasca ceremonies, all reported affirming their sexual orientation without negative impacts on their identity. Participants attributed improvements in various life areas to these experiences, highlighting the brew's potential as a tool for psychological resilience. This suggests that ayahuasca may play a vital role in supporting mental health and identity affirmation within marginalized communities.
Abstract
The practice of drinking ayahuasca-a psychoactive brew indigenous to the Amazon-has been investigated in several studies and shown to have positive...
Drug-induced psychosis following use of Ayahuasca: a presentation to forensic psychiatric services.
BMJ case reports – August 14, 2024
Summary
A healthy man with no prior mental health issues developed severe psychotic symptoms after using Ayahuasca, a traditional Amazonian psychedelic brew. Unlike typical cases, where drug-induced psychosis resolves quickly, his symptoms persisted and led to violence against a family member. After treatment with antipsychotic medication in a psychiatric facility, he achieved full recovery over 18 months.
Abstract
Ayahuasca is a plant-based psychoactive decoction, traditionally used by indigenous Amazonian peoples, which commonly contains the hallucinogen N,N...
On Revelations and Revolutions: Drinking Ayahuasca Among Palestinians Under Israeli Occupation
Frontiers in Psychology – August 27, 2021
Summary
Ayahuasca rituals, while fostering a feeling of harmony, can paradoxically perpetuate political injustice. Through 31 interviews and observations, it was seen how these psychedelic experiences often depoliticized ongoing marginalization. Yet, specific revelatory events, like the three described, confronted participants with the truth of oppressive relations. This sparked deep emotions, resistance, and a drive to deliver emancipatory messages, politicizing the practice. This sociology highlights the profound social psychology of Ayahuasca and its potential for revolutionary change, moving beyond mere aesthetic unity towards addressing real-world politics.
Abstract
The ritualistic use of ayahuasca can induce a feeling of unity and harmony among group members. However, such depoliticized feelings can come in th...
Ayahuasca in adolescence: Qaualitative results.
Journal of psychoactive drugs – June 01, 2005
Summary
Adolescents in legal, religious ayahuasca ceremonies appear as healthy and well-adjusted as non-using peers. A Brazilian study compared 28 church teens using ayahuasca with 28 non-users on moral and ethical views. Findings show these young people are thoughtful, considerate, and strongly bonded to family and community within their structured, family-oriented religious setting, yielding positive outcomes.
Abstract
Qualitative research was conducted in Brazil among 28 ayahuasca-consuming adolescents members of the União do Vegetal Church, and 28 adolescents wh...
Psychedelic-Assisted Therapy: Ayahuasca
OpenAlex – February 26, 2024
Summary
Psychedelic experiences, particularly with ayahuasca, can lead to profound therapeutic transformations. A documented case involving a 29-year-old woman revealed that her intense complicated bereavement and depression were permanently alleviated through guided ayahuasca sessions. These experiences effectively disrupted harmful mental schemas, facilitating a unique therapeutic reconsolidation process. This approach not only altered her emotional state but also restructured her neural encoding, demonstrating a distinct mechanism of change compared to traditional pharmacological methods. The implications for psychotherapy and medicine are significant.
Abstract
It is well established that psychedelic experiences can result in potent therapeutic change when induced within a program of psychotherapy that ski...
Christ returns from the jungle: Ayahuasca religion as mystical healing
Journal of Psychedelic Studies – August 16, 2024
Summary
Ayahuasca ceremonies in Europe provide vital solutions for individuals grappling with feelings of estrangement and isolation, effectively countering the secularization trend. Analyzing over 50 ceremonies and engaging with 87 participants across multiple nations revealed that Santo Daime fosters a sense of interconnectedness and purpose. Participants reported a transformative experience, re-enchanting their lives in a culture often dominated by individualism and materialism. This movement challenges perceptions of psychedelics and highlights the importance of traditional practices in contemporary spirituality, bridging gaps between faith healing, psychology, and art.
Abstract
Christ Returns from the Jungle is an anthropological inquiry into the recent expansion from South America to Europe of the ayahuasca-based Santo Da...