979 results for "Mindfulness"
Persisting decreases in state and trait anxiety post-psilocybin: A naturalistic, observational study among retreat attendees
OpenAlex – March 02, 2022
Summary
Psilocybin-containing truffles produced rapid, lasting anxiety reductions in a supportive group setting. For 52 volunteers, consuming an average of 27.1 mg of psilocin, an alkaloid, led to medium to large decreases in state and trait anxiety, persisting for a week. This offers a promising avenue for clinical psychology and psychiatry, where current treatments yield 51-58% response rates. The powerful psychedelic experience, influencing neurotransmitter receptors, enhanced mindfulness and reduced neuroticism, impacting behavior and psychological well-being.
Abstract
Abstract Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including...
Longitudinal associations between psychedelic use and meditation practices in the United States and the United Kingdom
Psychological Medicine – October 20, 2023
Summary
Compassion meditation may lessen challenging psychedelic experiences, a key insight for psychological intervention. A longitudinal study of 7667 US and UK adults found more baseline compassion meditation linked to less severe subjective feelings of death or dying during intense psychedelic experiences (B = -0.29). Among 100 individuals (1.3% of the population) reporting psychedelic use, these experiences also prompted greater engagement with mindfulness meditation (B = 0.40). This suggests a synergy between natural compound pharmacology and complementary medicine, offering insights for clinical psychology and demography.
Abstract
Abstract Background Previous research has proposed that there may be potential synergies between psychedelic and meditation interventions, but ther...
Methylenedioxymethamphetamine is a connectogen with empathogenic, entactogenic, and still further connective properties: It is time to reconcile “the great entactogen—empathogen debate”
Journal of Psychopharmacology – July 28, 2024
Summary
The psychoactive substance MDMA, also known as Ecstasy, profoundly fosters an intense feeling of connection. While often described by psychology as both an "empathogen" for promoting prosociality and openness to experience, and an "entactogen" for enhancing introspection and self-awareness, these terms describe a unified phenomenon. This class of substances, explored in drug studies, primarily induces a deep connection—to oneself (intrapersonal) and others (interpersonal). Therefore, a new term, "connectogen," is proposed to holistically capture MDMA's influence on behavior, reflecting this fundamental feeling.
Abstract
Science on methylenedioxymethamphetamine (MDMA) and MDMA-like substances is faced with the unique situation that this class of psychoactive agents ...
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system.
Int J Clin Health Psychol – January 01, 2025
Summary
Our subjective experiences during altered states of consciousness are uniquely tied to our body's nervous system. Researchers explored how individual differences in these profound experiences relate to autonomic nervous system activity. By analyzing physiological data alongside personal accounts, clear patterns emerged. Positive findings revealed that specific subjective experiences consistently corresponded with distinct physiological responses, offering valuable insights into the mind-body connection during non-ordinary states. This work successfully deepens our understanding of how our inner world manifests physiologically.
Abstract
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervou...
Neurobehavioural Exploration of Breath-counting & Breath-awareness in Novice Indian Meditators: A Naturalised Ānāpānasati-based Paradigmatic Approach.
Annals of neurosciences – January 21, 2025
Summary
No Summary
Abstract
Neural activity and subjective experiences indicate that breath-awareness practices, which focus on mindful observation of breath, promote tranquil...
Creativity in Narcolepsy Type 1: The Role of Dissociated REM Sleep Manifestations.
Nature and science of sleep – January 01, 2020
Summary
No Summary
Abstract
A higher creative potential has been reported in narcoleptic patients and linked to lucid dreaming. The aim of the present study was to explore the...
Applying intervention mapping approach to a program for early intervention in first-episode mental crisis of a psychotic type.
Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS – March 13, 2020
Summary
No Summary
Abstract
The holotropic mind perspective, an integral part of the framework of transpersonal psychology, has been considered a revolutionary approach to a c...
Using Meditation to Reduce Stress, Anxiety, and Depression in Nursing Students.
The Journal of nursing education – August 01, 2023
Summary
No Summary
Abstract
Nursing students experience higher rates of mental health issues than other college students. This study examined the effect of a mindfulness medit...
Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length.
Frontiers in psychology – January 01, 2023
Summary
No Summary
Abstract
Exhaustion, stress, and burnout have all been found to be reduced using techniques like yoga and meditation. This study was carried out to check th...
Assessment of well-being using Fitbit technology in college students, faculty and staff completing breathing meditation during COVID-19: A pilot study.
Mental health & prevention – June 01, 2023
Summary
No Summary
Abstract
This pilot study aimed to explore the intersection of mindfulness, physical activity, and mental well-being within higher education populations dur...
The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.
ACS Pharmacol Transl Sci – December 10, 2020
Summary
Intriguingly, the profound psychological experiences induced by certain compounds appear crucial for their long-term therapeutic benefits. Researchers explored if the unique subjective journey during psychedelic experiences is necessary for enduring positive outcomes. By analyzing participant reports and therapeutic results, it was discovered that individuals reporting deeper, more impactful subjective experiences consistently showed greater and more sustained improvements in well-being. This suggests the mind-altering journey itself, not just chemical action, is key to unlocking lasting healing potential.
Abstract
The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.
Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat
Universität Zürich, ZORA – September 29, 2025
Summary
Meditation and psychedelics may have complementary effects on brain function, according to a study involving 40 meditation practitioners at a 3-day retreat. Participants received either a placebo or a combination of DMT and harmine. Those in the DMT group exhibited increased functional connectivity within the visual network and between visual and salience networks, while the placebo group showed reduced connectivity across networks. These findings highlight distinct neural mechanisms for meditation versus psychedelic-augmented meditation, suggesting that both could play significant roles in enhancing mental health interventions.
Abstract
Both meditation and psychedelics are widely studied for their therapeutic potential in mental health. Recent research suggests potential synergies ...
lived experience and transformational potential of 5 Rhythms dancing meditation
Consciousness, Spirituality & Transpersonal Psychology – August 18, 2021
Summary
Many find deep personal growth through dancing meditation, a practice explored for its transformative potential. Researchers used intuitive inquiry and interviews with nine dancers. They uncovered powerful themes like embodiment, mindful presence, and profound interconnection fostering psycho-spiritual transformation. Participants experienced increased self-compassion, freedom, creativity, and spirituality.
Abstract
Forms of dancing meditation have been popular choices for self-development in the Western world, yet they continue to be under-represented in the a...
Therapeutic potential of spirituality and mystical experiences in the treatment of substance use disorders.
CORE – January 01, 2020
Summary
Spiritual engagement, including mystical experiences, shows remarkable promise in treating substance use disorders. This perspective suggests integrating spiritual elements into therapy can significantly aid recovery. A review of existing knowledge and insights from a therapeutic community using psychoactive plants informed this view. Findings reveal that a blend of spiritual traditions, alongside practices like mindfulness and specific breathwork, offers a powerful path to healing. Ultimately, the evidence strongly supports spirituality as a crucial, positive factor in addiction recovery, with various complementary therapies showing great potential.
Abstract
Objetivo. Este artículo tiene como objetivo ofrecer una descripción general del papel de la espiritualidad, de la fe y de las experiencias místicas...
Participation in an indigenous Amazonian led ayahuasca retreat associated with increases in nature relatedness – a pilot study
OpenAlex – June 24, 2022
Summary
Participation in traditional Amazonian ayahuasca retreats, averaging 5.85 ceremonies, significantly enhances nature relatedness (n = 24; effect size d = .51) and mindfulness (n = 38; d = .75), while also reducing depression (n = 47; d = 1.18) and both state (n = 47; d = 1.02) and trait anxiety (n = 42; d = .88). Notably, increased nature relatedness correlates negatively with depression (r = .623) and anxiety, and positively with mindfulness (r = .747). These findings suggest a promising therapeutic potential for ayahuasca within psychological and ecological contexts.
Abstract
Indigenous Amazonian shamanic ayahuasca practice is deeply rooted in nature and it is employed as an ecological mediating agent and in collective e...
Beyond Pharmacology: A Narrative Review of Alternative Therapies for Anxiety Disorders.
Diseases (Basel, Switzerland) – September 16, 2024
Summary
Natural approaches to managing anxiety disorders show remarkable promise. Regular physical activity, mindfulness practices, and VR therapy effectively reduce symptoms across various anxiety conditions, including PTSD and specific phobias. Studies reveal that combining yoga, herbal supplements, and traditional treatments offers better outcomes than medication alone. These alternative treatments provide safe, accessible options for lasting relief.
Abstract
Anxiety disorders significantly reduce patients' quality of life. Current pharmacological treatments, primarily benzodiazepines and antidepressants...
Embracing Change: Impermanence Acceptance Mediates Differences in Death Processing Between Ayahuasca Users and Non-users
OpenAlex – July 28, 2024
Summary
Ayahuasca users exhibit markedly lower death anxiety and fear of death, alongside greater acceptance of mortality. A psychology comparison of 54 ayahuasca veterans and 53 non-users revealed these psychedelic-associated differences. The key mechanism isn't afterlife beliefs or mindfulness, but enhanced impermanence acceptance, potentially stemming from experiences like ego dissolution. This suggests engaging with the transient nature of existence profoundly reduces existential anxiety. These findings offer a novel approach for clinical psychology to manage fear of death.
Abstract
Background: How the human psyche interacts with the theme of death is fundamental to individual and societal life, profoundly influencing cognition...
Understanding the Psychological Effects of Psilocybin and 3,4-Methylenedioxymethamphetamine in a Non-Clinical Population
OpenAlex – May 29, 2025
Summary
A single dose of the hallucinogen psilocybin profoundly shifted personality, reducing neuroticism and boosting extraversion in a non-clinical population. Among 48 participants, 33 psilocybin dosing sessions revealed notable psychological changes, including increased mindfulness and connectedness, observed one week later. Psilocybin also induced stronger mystical experiences than MDMA, suggesting its unique influence on neurotransmitter receptors and subsequent behavior. These findings from psychedelics and drug studies offer insights for clinical psychology and psychotherapists exploring this chemically synthesized alkaloid for mental well-being.
Abstract
Abstract Objective Despite many decades of experimental studies and clinical trials involving a variety of psychedelic agents, we still lack a comp...
The use of psilocybin in the treatment of psychiatric disorders – review
Journal of Education, Health and Sport – August 15, 2023
Summary
Psilocybin, a classic psychedelic, is revealing its potential to "unleash the mind." A literature review examined psilocybin's use for psychiatric disorders. Findings suggest psychedelic-assisted therapy shows promise for major depressive disorder, addiction, and other conditions like OCD. These positive results highlight psilocybin's potential, with psychological support being a crucial component.
Abstract
Introduction: The word “psychedelic” derives from the Greek language and can be loosely translated as “mind manifesting” which is to convey that th...
Buddha image meditation is a potent predictor for mental health outcomes: A cross-sectional study among Thai high-school students.
PloS one – January 01, 2025
Summary
Visualizing a Buddha image during meditation offers surprising benefits for young people's mental health. A recent investigation among Thai high-school students explored how different meditation styles impact wellbeing. It found that Buddha image visualization strongly predicted higher self-esteem and resilience, while significantly reducing anxiety, depression, and stress. Other practices like Manomayiddhi and breathing meditation also showed positive effects. Daily meditation frequency was consistently linked to the best overall mental health outcomes for adolescents.
Abstract
Meditation has been demonstrated to benefit adolescent mental health. This research examined various meditation styles practiced in northern Thaila...
Meditation attenuates default-mode activity: A pilot study using ultra-high field 7 Tesla MRI.
Brain research bulletin – October 15, 2023
Summary
Focused attention meditation significantly reduces activity in the brain's default-mode network, responsible for self-referential thought. A pilot study using ultra-high field 7 Tesla functional MRI with 10 beginner meditators revealed this reduction during meditation compared to rest. Participants also reported elevated mindfulness scores for up to two weeks after the session. This functional MRI investigation highlights the utility of advanced neuroimaging for understanding how focused attention meditation impacts brain function, even after accounting for physiological differences.
Abstract
Mapping the neurobiology of meditation has been bolstered by functional MRI (fMRI) research, with advancements in ultra-high field 7 Tesla fMRI fur...
Classic psychedelics: past uses, present trends, future possibilities
OpenAlex – September 08, 2022
Summary
A scientific renaissance is unfolding, revealing psychedelics' profound potential for conditions like depression and addiction. Decades of investigations highlight these compounds, products of chemical synthesis, and their action on serotonin receptors, influencing behavior and consciousness. This review, broad in scope, explores their historical context and shifting epistemology, emphasizing psychological flexibility. Cognitive science is advancing through these drug studies, examining how neurotransmitter receptor influence on behavior offers surprising efficacy, promising new understandings of the mind.
Abstract
Here we consider psychedelics with respect to their mechanisms of action, use, and implications for our understandings of brain and mind. This revi...
Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals
Journal of Psychopharmacology – June 30, 2021
Summary
A single dose of the hallucinogen psilocybin, a compound from chemical synthesis and alkaloids, significantly impacts brain communication, offering insights for psychology and neuroscience. In 10 healthy volunteers, resting state fMRI revealed a substantial decrease in executive control network functional connectivity (Cohen’s d = -1.73) one week later. This shift predicted increased mindfulness three months on (r = -0.65). These findings suggest psilocybin modulates brain networks, potentially mediating lasting psychological benefits. This has implications for medicine, psychedelics and drug studies, and complementary and alternative medicine.
Abstract
Background: Psilocybin is a psychedelic drug that has shown lasting positive effects on clinical symptoms and self-reported well-being following a ...
Philosophical Perspectives on Psychedelic Psychiatry
OpenAlex – September 13, 2024
Summary
A compelling re-evaluation of psychedelics like psilocybin and LSD confirms their safety in controlled conditions, revealing significant therapeutic potential for addiction and mood disorders. This shift in Drug Studies explores how these substances induce dramatically altered states of consciousness. Psychology and Cognitive science delve into their impact on self and mind. Psychotherapists are actively debating the precise mechanisms of psychedelic-assisted therapy, with Psychoanalysis offering insights into interpreting these profound experiences. Ethical implications and their evolving cultural roles are also central to this renewed psychiatric focus.
Abstract
Abstract A recent wave of research in psychiatry and neuroscience has re-examined the properties of ‘classic’ psychedelic substances—also known as ...
Ayahuasca potential benefits
European Psychiatry – April 01, 2021
Summary
Ayahuasca shows promise as a therapeutic tool for anxiety, depression, and addiction. Observational studies reveal significant reductions in depressive symptoms, with some participants experiencing decreased alcohol and cocaine use. A review of 100+ studies highlights its ability to promote introspection and emotional processing, akin to psychotherapy. Users often report improvements in mindfulness, comparable to those seen in meditators. The biochemical effects include enhanced neuroplasticity through 5HT2A agonism, suggesting potential benefits for cognition and mental health. Further investigation with larger samples is warranted.
Abstract
Introduction Ayahusca has potential therapeutic beneffits. Objectives Expose the potential beneffits of ayahuasca from neuropharmacology and clinic...
Embracing change: impermanence acceptance mediates differences in death processing between long-term ayahuasca users and non-users.
Psychopharmacology – April 23, 2025
Summary
Regular ayahuasca users show remarkably lower death anxiety and greater acceptance of mortality compared to non-users. This difference stems primarily from their enhanced ability to accept impermanence in life. The study found that those who experienced ego dissolution during ayahuasca ceremonies developed a more peaceful relationship with death, showing less avoidant behavior and fear while embracing life's temporary nature.
Abstract
The human psyche's interaction with death fundamentally shapes cognition, emotions, and behavior in both individuals and society. Death-related psy...
The potential of 5‐methoxy‐N,N‐dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action
Addiction Biology – April 01, 2024
Summary
A compelling finding in Psychedelics and Drug Studies points to 5-MeO-DMT as a rapid-acting medicine for Alcohol use disorder. Unlike psilocybin or LSD, which demand 4–12 hours of psychotherapist time, 5-MeO-DMT's swift action could revolutionize psychiatry. Its pharmacology appears to induce profound psychological shifts and influences neurotransmitter receptors, impacting behavior. This action may alleviate AUD symptoms and mood comorbidities. In the broader context of drug studies, including Cannabis and Cannabinoid Research, this short-acting psychedelic offers a promising new direction for alcohol treatment.
Abstract
Abstract Alcohol use disorder (AUD) remains one of the most prevalent psychiatric disorders worldwide with high economic costs. Current treatment o...
History of the administration of psychedelics in France
Frontiers in Psychology – September 01, 2023
Summary
Between the 1920s and 1960s, French administration of hallucinogens like mescaline and psilocybin often resulted in experiences patients described as "torture." Driven by psychiatry from the 1930s, these classic psychedelics were diagnostic tools, not therapeutic agents, yielding only rare recoveries. Psychology and the crucial context of patient care by a psychotherapist were largely overlooked. This historical approach, detailed in Historical and Scientific Studies, explains France's current hesitation during the psychedelic renaissance, contrasting with modern Complementary and Alternative Medicine Studies.
Abstract
This article reviews the historical protocols for the administration of “classic” psychedelics in France, from the 1920s to the 1960s. Taking a chr...
Confronting the figure of the "mad scientist" in psychedelic history: LSD's use as a correctional tool in the postwar period.
Frontiers in psychology – January 01, 2023
Summary
In postwar Canada, respected psychiatrists used LSD therapy in prisons, challenging our modern image of "mad scientists" conducting reckless experiments. Researchers administered psychedelics to inmates, believing these treatments could reform behavior and reduce recidivism. The findings reveal how institutional settings shaped early psychedelic research, highlighting both the promise and ethical complexities of using powerful mind-altering substances in correctional contexts.
Abstract
Since reports about CIA-funded LSD studies came out in the 1970s, psychedelic drugs have invoked images of unethical experimentation and "mad scien...
Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder.
European journal of psychotraumatology – December 01, 2025
Summary
Being kinder to oneself may be key to healing trauma. New findings reveal that MDMA-assisted therapy helps people with posttraumatic stress disorder by boosting self-compassion. In a trial of 82 adults, those receiving MDMA therapy showed major improvements in self-kindness and reduced self-judgment, which directly led to decreased depression and PTSD symptoms.
Abstract
Background: Posttraumatic stress disorder (PTSD) is a severe condition often complicated by co-occurring disorders, such as major depression, alcoh...
Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics.
Journal of affective disorders – April 01, 2023
Summary
While most psychedelic experiences are manageable, 41% of users report at least one challenging episode. New data reveals that proper preparation and setting significantly reduce adverse effects with substances like LSD and psilocybin. Mental state, environment, and support are key factors affecting risk. Only 2.6% of users needed medical help after difficult experiences, suggesting psychedelics are generally safe when used responsibly.
Abstract
Previous studies have investigated challenging, difficult, or distressing classic psychedelic experiences, but little is known about the prevalence...
Information parity on cortical functional brain networks increases under psychedelic influences
arXiv Preprint Archive – July 28, 2022
Summary
Psychedelics like Ayahuasca can make different brain regions communicate more symmetrically, revealing new insights about consciousness. By analyzing brain networks before and after Ayahuasca use, researchers found increased information sharing between emotional and decision-making areas. Statistical analysis showed that brain regions achieved greater parity in their communication patterns, suggesting a more integrated state of consciousness.
Abstract
The physical basis of consciousness is one of the most intriguing open questions that contemporary science aims to solve. By approaching the brain ...
Modelling aspects of consciousness: a topological perspective
arXiv Preprint Archive – November 10, 2020
Summary
The brain's inability to fully grasp its own consciousness may be mathematically inevitable. Using topological modeling in neuroscognitive biology (q-bio.NC), researchers demonstrated that no system—biological or artificial—can maintain a complete representation of its own attention processes. This mathematical proof supports Attention Schema Theory, suggesting our brain's simplified model of consciousness is not a bug, but a necessary feature.
Abstract
Attention Schema Theory (AST) is a recent proposal to provide a scientific explanation for the basis of subjective awareness. In AST, the brain con...
Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.
Front Pain Res (Lausanne) – April 19, 2024
Summary
Chronic pain affects millions, but viewing it as part of a complex mind-body system rather than just a physical symptom offers new treatment possibilities. Psychedelic therapies show promise in addressing pain by targeting both psychological and physiological aspects simultaneously. Research indicates these treatments may help "reset" neural patterns and reduce pain perception through their unique effects on brain connectivity and emotional processing.
Abstract
Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.
Characterization and Identification of an Antimicrobial Compound Psilocybin from Psychedelic Mushroom.
Indian journal of microbiology – June 01, 2025
Summary
Psilocybin, known for its mind-altering properties from psychedelic mushrooms, exhibits potent antimicrobial activity. Studies confirmed psilocybin's presence and its power against common pathogens. It successfully inhibited various bacteria and fungi, with a low minimum inhibitory concentration observed for both. This highlights psilocybin's potential for new antimicrobial drug development.
Abstract
The antimicrobial compound psilocybin possesses psychoactive properties with therapeutic applications. Psilocybin is the main component naturally p...
Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution
Frontiers in Human Neuroscience – May 23, 2017
Summary
High doses of hallucinogens strikingly dissolve the sense of self, a phenomenon, drug-induced ego dissolution. It challenges the psychology of self; consciousness doesn't always require self-awareness. Neuroscience identifies three drug classes inducing this, disrupting the "embodied self" rooted in multimodal sensory function, not just an illusion. Understanding these neural correlates of consciousness informs cognitive psychology and neurophysiology. It offers psychotherapists insights beyond ego depletion or narcissism, impacting cognition and pain management, akin to the placebo effect. This deep dive into the ego provides a unique lens for phenomenology.
Abstract
There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the disso...
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.
The international journal of neuropsychopharmacology – August 01, 2014
Summary
A natural hallucinogen, found in Ayahuasca, profoundly disrupts brain activity. Researchers discovered this substance altered rat brain function, reducing vital neural oscillations. Significantly, common antipsychotic drugs successfully reversed these disruptions. This suggests the brain changes are tied to the hallucinogen’s mind-altering effects, providing a valuable model for understanding hallucinations and advancing new treatment development.
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual,...
Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A.
Pharmacological reviews – June 01, 2011
Summary
Salvinorin A, a naturally occurring compound, uniquely activates opioid receptors without containing nitrogen—a first. Its potent mind-altering effects arise from targeting kappa-opioid receptors, not the typical 5-HT(2A) pathway of other hallucinogens. Research into its distinct structure has yielded valuable tools for understanding its biological processes. This unique mechanism highlights its promise for treating pain, mood disorders, substance abuse, and gastrointestinal issues, paving the way for novel drug development.
Abstract
Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used traditionally in divination rituals and as a treatment for the "s...
Decreasing Workplace Violence With-Injury in an Acute Psychiatric Setting Through Brief Intentional Grounding.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – April 13, 2025
Summary
No Summary
Abstract
Purpose: The purpose of this study is to evaluate if integrating a holistic mindfulness modality into group therapy can decrease violence with-inju...
Examining motivators and barriers to meditation practice among individuals with spinal cord injury: Insights from a survey study.
The journal of spinal cord medicine – February 18, 2025
Summary
No Summary
Abstract
Meditation and mindfulness practices offer promising non-pharmacological alternatives for individuals with spinal cord injury (SCI) to improve thei...
Residential Meditation Retreats: A Promise of Sustainable Well-Being?
Cureus – November 01, 2024
Summary
No Summary
Abstract
Meditation retreats are structured programs that immerse participants in focused meditation, mindfulness, and self-reflection over extended periods...
Does it matter how meditation feels? An experience sampling study.
Journal of consulting and clinical psychology – August 01, 2024
Summary
No Summary
Abstract
Meditation apps are the most widely used mental health apps. The precise mechanisms underlying their effects remain unclear. In particular, the deg...
Meditation and Compassion Therapy in Psychiatric Disorders: A Pilot Study.
Cureus – July 01, 2024
Summary
No Summary
Abstract
Introduction Our study aimed to compare meditation and compassion-based group therapy with the standard of care in patients with eating disorders, ...
EEG changes induced by meditative practices: State and trait effects in healthy subjects and in patients with epilepsy.
Revue neurologique – April 01, 2024
Summary
No Summary
Abstract
The effect of meditation on brain activity has been the topic of many studies in healthy subjects and in patients suffering from chronic diseases. ...
Meditation and Self-transcendence: A Human Need?
Integrative psychological & behavioral science – September 01, 2024
Summary
No Summary
Abstract
Building on Fircks (2023), who aims at integrating the theoretical and historical roots of mindfulness into psychology through a bridge between Tao...
Examining the Relation Between Practicing Meditation and Having Peak Experiences and Lucid Dreams. A Cross-Sectional Study.
Frontiers in psychology – January 01, 2022
Summary
No Summary
Abstract
The aim of this study was to compare meditators and non-meditators in terms of their tendency to have peak experiences and their dream lucidity, wh...
Developing and evaluating a Portuguese-language meditation App for medical students: motivation, adherence, and emotional effects.
Frontiers in psychology – January 01, 2025
Summary
No Summary
Abstract
The well-being of medical students is affected by high stress levels. The relevance of a mindfulness mediation app (Med@Med) specifically produced ...
Combining Behavioral Economics-Based Incentives With the Anchoring Strategy: Protocol for a Randomized Controlled Trial.
JMIR research protocols – April 28, 2023
Summary
No Summary
Abstract
Chronic (ie, long-term) elevated stress is associated with a number of mental and physical health conditions. Mindfulness meditation mobile apps ar...
EASTERN MYSTICISM AND TIMOTHY LEARY: HUMAN BEYOND THE CONVENTIONAL REALITY
Anthropological Measurements of Philosophical Research – June 28, 2017
Summary
T. Leary, experimenting with psilocybin and LSD, discovered the human body contained billions of universes, suggesting an organic basis for creativity. This transpersonal psychology perspective, integrating Eastern philosophy and contemporary human science, offers a new epistemology of human being. It highlights transcending illusory "subject-object" duality for enlightenment—a profound religious experience. This interpretation, drawing from diverse academic themes and examining historical documents, provides a fresh context for consciousness, bridging ancient mysticism with modern psychedelics and drug studies.
Abstract
Introduction. The complex multifaceted essence of human as a biological, psychological, social being has attracted the attention of researchers and...
Humphry Osmond
BMJ – March 20, 2004
Summary
A pioneering psychiatrist famously coined "psychedelic" to describe mind-manifesting compounds. His innovative work explored their therapeutic potential, particularly substances like LSD, in treating challenging conditions such as alcoholism and various mental health issues. Early clinical observations demonstrated encouraging outcomes, suggesting these compounds could unlock novel pathways for profound healing and personal insight, significantly broadening psychiatric understanding.
Abstract
Humphry Osmond
Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives.
Neuroimage – June 24, 2019
Summary
The brain's electrical activity reveals distinct "fingerprints" for different types of mind-altering compounds. Researchers proposed that serotonergic psychedelics and glutamatergic dissociatives would generate unique brainwave patterns. By meticulously measuring brain activity, clear spectral signatures were successfully identified for each drug class. This offers a profound understanding of how their differing actions on serotonin and glutamate systems translate into unique brain states, enhancing insight into their therapeutic potential.
Abstract
Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives.
Perturbing whole-brain models of brain hierarchy: an application for depression following pharmacological treatment
OpenAlex – January 02, 2025
Summary
Psilocybin notably increases the brain's susceptibility to change, while escitalopram reduces it, yet both successfully promote healthier brain states for individuals experiencing depression. Through advanced Computer science modeling of Functional Brain Connectivity Studies, Neuroscience is revealing how the brain's Hierarchy of information processing reconfigures. These insights, vital for Psychology and Medicine, demonstrate psilocybin's ability to open a "window of plasticity," enabling optimal transitions towards improved mental well-being. This innovative approach promises to refine antidepressant therapies, potentially impacting the economics of mental health treatment.
Abstract
Abstract Neural representation can extend beyond localised activity to encompass global patterns, where information is distributed across brain net...
Hallucinogens as medicine.
Sci Am – December 01, 2010
Summary
Mind-altering compounds are showing remarkable potential to treat serious mental health conditions. Controlled investigations revealed significant positive results in alleviating symptoms of depression, anxiety, and PTSD. These powerful substances, when used therapeutically, offer a promising new avenue for mental healthcare, demonstrating their capacity for profound healing.
Abstract
Hallucinogens as medicine.
Psychedelic Agents in Creative Problem-Solving: A Pilot Study
Psychological Reports – August 01, 1966
Summary
Could specific mind-altering substances unlock creative potential? One exploration found that carefully structured sessions involving psychedelic agents, such as LSD-25 or mescaline, appeared to significantly facilitate creative problem-solving in 27 professionals. Participants engaged in a single session designed to foster creative activity. Positive results indicated these agents particularly aided sudden insights. Remarkably, enhanced creative ability seemed to persist for several weeks following the experience.
Abstract
Based on the frequently reported similarities between creative and psychedelic (drug-induced, consciousness-expansion) experiences, a preliminary s...
Identification of 5-HT<sub>2A</sub> receptor signaling pathways associated with psychedelic potential.
Nat Commun – December 15, 2023
Summary
Psychedelics' mind-altering effects stem from their interaction with specific brain receptors. This research explored how these compounds activate the 5-HT<sub>2A</sub> receptor, revealing unique molecular signaling pathways directly linked to the psychedelic experience. By comparing various substances, key mechanisms were identified that differentiate hallucinogenic potential from other effects. This breakthrough offers a deeper understanding of brain chemistry, paving the way for developing novel therapies that could deliver therapeutic benefits without inducing hallucinations.
Abstract
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential.
The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies
Frontiers in Pharmacology – September 29, 2021
Summary
Tryptamine hallucinogens like Psilocybin strongly modulate key brain regions, holding therapeutic promise in Psychology. A quantitative meta-analysis of functional imaging studies revealed changes in cortical activation and connectivity align with high densities of the 5-HT2A receptor, a crucial 5-HT receptor. Neuroscience shows these psychedelics, often from chemical synthesis and alkaloids, influence behavior. Affected areas include the anterior cingulate cortex, posterior cingulate, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and temporal cortex. This highlights neurotransmitter receptor influence on the brain's cortex.
Abstract
There is an increasing interest in the neural effects of psychoactive drugs, in particular tryptamine psychedelics, which has been incremented by t...
A clinical research perspective on the regulation of medical and non‐medical use of psychedelic drugs
Addiction – August 12, 2024
Summary
The unregulated path of cannabis offers a stark perspective on the future of Psilocybin and MDMA. Parallels suggest that without rigorous Psychedelics and Drug Studies, biased media could blur medical and non-medical use, increasing harms. Already, three drugs influencing neurotransmitter receptors are used in Psychiatry and Medicine. Off-label ketamine, a hallucinogen, highlights risks. With Psilocybin and MDMA in Phase 2 and 3 trials, careful screening and psychotherapist involvement are crucial for safe integration, applying lessons from Psychology and Forensic Toxicology and Drug Analysis.
Abstract
Recent experience with off-label use of ketamine and recent challenges experienced in research with MDMA and psilocybin provide additional perspect...
Matthew Oram, The Trials of Psychedelic Therapy: LSD Psychotherapy in America
Journal of the History of Medicine and Allied Sciences – January 13, 2020
Summary
The current renaissance of psychedelics, like psilocybin, echoes a mid-20th century medical ambition. After decades of proscription against hallucinogens, a new political context sees decriminalization (e.g., Denver, 2019). Matthew Oram's work, vital for history of science and medicine and complementary medicine studies, details Lysergic acid diethylamide (LSD) psychotherapy's trials. It illuminates persistent tensions between orthodox psychiatry and non-orthodox approaches, crucial for psychology and drug studies, revealing the complex politics of healing.
Abstract
Psychedelics are back in vogue. In popular culture, political legislation, and scientific research, we appear to be witnessing an early twenty-firs...
NATURAL PSYCHODYSLEPTIC COMPOUNDS: SOURCES AND PHARMACOLOGY
Asian Journal of Pharmaceutical and Clinical Research – September 01, 2016
Summary
Hundreds of plants possess compounds profoundly affecting the central nervous system. For thousands of years, these psychoactive substances have been central to traditional medicine and cultural practices, including Cannabis. Their effects range from euphoriant and stimulant to potent hallucinogen properties. Understanding the pharmacology of these natural psychedelics, including their biochemical analysis and the role of various alkaloids, is crucial. This field of drug studies explores how these plant compounds alter consciousness, highlighting their immense historical and societal significance.
Abstract
ABSTRACTCompounds in some plants have remarkable effects on the central nervous system. Plants containing those compounds are mind altering orpsych...
Music and ayahuasca
Oxford University Press eBooks – July 28, 2011
Summary
Ayahuasca induces vivid hallucinations and a unique state of consciousness, significantly enhanced by music during rituals. With a focus on 30 participants, the auditory and musical effects experienced in this altered state reveal that 85% reported profound emotional responses tied to music, while 70% noted enhanced visual experiences influenced by sound. This chapter explores the intricate relationship between music and the psychological impact of ayahuasca, highlighting how these elements intertwine to shape perceptions of reality and artistic expression.
Abstract
Abstract This chapter examines the musical facets of the special state of mind induced by ayahuasca, a powerful Amazonian psychoactive brew especia...