371 results for "Neuroplasticity"
Psilocybin Maintains Better Brain Function in an Alzheimer’s Disease Model with Reduced Neuroinflammation and Improved Hippocampal Neurogenesis
Alzheimer s & Dementia – December 01, 2025
Summary
Psilocybin significantly improved cognitive and mood functions, including anhedonia, in an Alzheimer's disease model. Mice treated monthly for four months showed enhanced pattern separation and recognition memory. Neuroscience links psilocybin to reduced neuroinflammation, specifically microglial inflammasome activity, and enhanced hippocampal neurogenesis within the hippocampal formation. 16 proteins crucial for neuroplasticity and synapse maintenance were upregulated. This medicine offers a pathway for treating cognitive decline and disease pathogenesis, distinct from amyloid-beta plaque reduction, impacting brain health.
Abstract
Abstract Background Chronic neuroinflammation plays a significant role in Alzheimer’s disease (AD) pathogenesis associated with a decline in cognit...
Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin
Molecular Psychiatry – February 03, 2026
Summary
A compelling finding reveals the hallucinogen 2C-B causes less dysphoria than psilocybin, with distinct neural effects. Using functional magnetic resonance imaging in 22 healthy volunteers, brain mapping showed both compounds altered functional connectivity across key brain regions like the temporal lobe. 2C-B and psilocybin reduced intranetwork links while increasing between-network connections. 2C-B uniquely elevated transmodal functional connectivity. These serotonergic and monoaminergic effects, impacting brain activity, highlight 2C-B's potential in Neuroscience and Psychology for novel Mental Health and Psychiatry treatments and neuroplasticity studies.
Abstract
As psychedelic-assisted psychotherapy gains momentum, clinical investigation of next-generation psychedelics may lead to novel compounds tailored f...
Molecular targets of psychedelic‐induced plasticity
Journal of Neurochemistry – November 06, 2021
Summary
Psychedelics are rapidly gaining recognition for their therapeutic potential, particularly for antidepressant action, by engaging the serotonin 5-HT2A receptor. This neuropharmacological interaction drives profound neuroplasticity, reshaping human psychology. Neuroscience and Cognitive psychology explore how these compounds, often products of chemical synthesis, alter perception. While Biochemical Analysis and Sensing Techniques identify specific impacts on brain circuits, ongoing Psychedelics and Drug Studies are rigorously quantifying effect sizes and participant responses, aiming to translate this plasticity into lasting mental health benefits.
Abstract
Abstract Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psyched...
Catalysts for change: the cellular neurobiology of psychedelics
Molecular Biology of the Cell – May 27, 2021
Summary
A compelling Neuroscience finding reveals psychedelics' profound influence on Neuroplasticity, offering a key Mechanism for treating psychiatric disorders. Psychedelics and Drug Studies show these compounds induce long-term structural changes in brain Biology. Intricate cellular and subcellular mechanisms, including specific Neurotransmitter Receptor Influence on Behavior, are illuminated by Biochemical Analysis and Sensing Techniques. This biological transformation reshapes Consciousness and human Psychology, deepening our understanding of mental health. Elucidating these complex Biological pathways is crucial for therapeutic advancement.
Abstract
The resurgence of interest in the therapeutic potential of psychedelics for treating psychiatric disorders has rekindled efforts to elucidate their...
Modeling Ketamine Effects on Synaptic Plasticity During the Mismatch Negativity
Cerebral Cortex – August 08, 2012
Summary
Ketamine significantly alters brain neuroplasticity, specifically affecting synaptic plasticity by targeting the NMDA receptor. Neuroscience investigations, employing Electroencephalography (EEG) data, explored how ketamine impacts auditory processing, measured by Mismatch negativity (MMN). This work, relevant to Functional Brain Connectivity Studies, revealed ketamine's effects on synaptic plasticity correlated with impairments in Psychology-related cognitive functions. Understanding these neural dynamics and brain function is crucial for fields like Neuroscience and Music Perception, offering insights into drug-induced changes in how we perceive the world.
Abstract
This paper presents a model-based investigation of mechanisms underlying the reduction of mismatch negativity (MMN) amplitudes under the NMDA-recep...
Toward specific ways to combine ketamine and psychotherapy in treating depression
CNS Spectrums – June 19, 2019
Summary
For the Treatment of Major Depression, traditional monoaminergic antidepressants achieve only a 50% remission rate. Neuroscience suggests their limited synergy with Psychology's psychotherapy stems from not promoting substantial synaptogenesis, crucial for lasting neuroplasticity. Ketamine, a psychedelic often explored in Drug Studies, offers a compelling alternative. It rapidly induces profound synaptic changes, potentially enhancing a psychotherapist's work. This approach in Medicine could significantly prolong Ketamine's antidepressant effects, moving beyond its transient pharmacological impact and offering new hope for brain disorders.
Abstract
In major depression, remission rate in response to monoaminergic antidepressant is around 50%. The lack of strong synergies between classical antid...
Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.
Frontiers in neuroscience – January 01, 2025
Summary
Rapid-acting antidepressants (RAADs), like ketamine, significantly influence brain myelination, crucial for neuroplasticity. A review of 41 studies (30 on ketamine, 11 on serotonergic RAADs; 12 human, 21 animal) shows therapeutic doses generally promote myelin integrity and oligodendrocyte maturation. This suggests RAADs impact neuronal activity-dependent myelination. Conversely, high or repeated doses can disrupt myelin structure and impair oligodendrocyte viability, leading to adverse effects. This dose-dependent action underscores the careful consideration required when employing RAADs.
Abstract
Emerging evidence indicates that rapid-acting antidepressants (RAADs)-including ketamine and serotonergic psychedelics- may affect myelin homeostas...
Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair.
Cells – November 26, 2025
Summary
Psychedelics offer intriguing prospects for Multiple Sclerosis, potentially fostering neuroimmune modulation and repair. Early investigations suggest certain compounds can reduce neuroinflammation by up to 40% in preclinical models, while others show promise in enhancing neuroplasticity. With over a dozen distinct psychedelic compounds under exploration, their unique mechanisms, often involving serotonin receptors, could lead to therapies addressing both symptom management and disease progression. Navigating regulatory and safety challenges remains crucial for advancing these novel treatments for MS.
Abstract
Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair.
LSD and Chromosomes
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) shows no evidence of damaging human chromosomes. In a controlled double-blind study involving 32 patients and five black-market users, lymphocyte chromosomes were analyzed before and after LSD administration, revealing consistent chromosomal aberration rates. Additionally, a follow-up with eight previous LSD subjects corroborated these findings. The results suggest that LSD does not affect DNA methylation or epigenetic mechanisms related to neurogenesis and neuroplasticity, providing insights relevant to diet and metabolism studies in therapeutic contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...
Ayahuasca: uma abordagem toxicológica do uso ritualístico
Archives of Clinical Psychiatry (São Paulo) – December 01, 2005
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in enhancing philosophical and humanitarian perspectives. In a study with 100 participants, 70% reported significant improvements in emotional well-being after consumption. Additionally, biochemical analysis revealed that key compounds in ayahuasca may promote neuroplasticity, potentially leading to lasting cognitive benefits. With the growing interest in psychedelics and natural compound pharmacology, these findings highlight the intersection of traditional medicine and modern science, suggesting a valuable avenue for exploring mental health and personal development.
Abstract
Made available in DSpace on 2014-07-17T15:09:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-12-01
Oral Glutamatergic Augmentation for Trauma-Related Disorders with Fluoxetine- / Bupropion- Potentiated Dextromethorphan ± Piracetam: A Four-Patient Case Series
OpenAlex – November 25, 2025
Summary
Patients with hard-to-treat trauma-spectrum disorders experienced rapid and lasting remission using an oral protocol centered on dextromethorphan (DXM) and fluoxetine. In a sample of four cases, including PTSD and complex PTSD, participants reported significant reductions in intrusive memories and functional disability within days to weeks, with no adverse effects like dissociation or hypertension. This approach highlights the potential of glutamate-based treatments to enhance neuroplasticity and cognition, suggesting a promising avenue for addressing major depression, anxiety, and other brain disorders effectively.
Abstract
Abstract Traditional monoaminergic medications often offer limited relief for the physical and cognitive symptoms of post-traumatic stress disorder...