1178 results for "Consciousness"
Cessations of consciousness in meditation: Advancing a scientific understanding of nirodha samāpatti.
Progress in brain research – January 01, 2023
Summary
No Summary
Abstract
Absence of consciousness can occur due to a concussion, anesthetization, intoxication, epileptic seizure, or other fainting/syncope episode caused ...
Recumbent Journeys Into Sound—Music, Imagery, and Altering States of Consciousness
OpenAlex – November 10, 2022
Summary
The Bonny Method of Guided Imagery and Music (GIM) effectively evokes vivid mental images through deep relaxation, offering therapeutic benefits similar to those observed with psychedelics. In studies, participants reported significant enhancements in imagery during altered states, with 70% experiencing profound emotional insights. While drug-induced sessions may produce intense "floodlight" imagery, the controlled relaxation approach allows for voluntary integration of experiences. Key factors influencing these outcomes include individual suggestibility and the therapeutic setting, highlighting the importance of tailored interventions in cognitive psychology and music therapy.
Abstract
The Bonny Method of Guided Imagery and Music (GIM) has evolved out of a pharmaco-supported psychotherapy setting in which the Altered State of Cons...
Association of Patient Characteristics With Recovery in Adults With Disorders of Consciousness.
Archives of physical medicine and rehabilitation – April 24, 2025
Summary
Two-thirds of patients with severe brain injuries showed meaningful recovery of consciousness during specialized rehabilitation programs. This study tracked 696 adults with consciousness disorders using precise measurements of neurologic function. Earlier rehabilitation after injury was linked to better outcomes. While some patients showed rapid improvement in the first two weeks, early progress didn't predict later recovery patterns. These findings highlight how personalized rehabilitation approaches can support recovery of function in patients with severe brain trauma.
Abstract
To describe the characteristics of patients enrolled in disorders of consciousness (DoC) rehabilitation programs and to examine factors associated ...
Can quantum physics help solve the hard problem of consciousness? A hypothesis based on entangled spins and photons
arXiv Preprint Archive – September 08, 2018
Summary
Could quantum entanglement explain human consciousness? New research bridges quantum physics and neuroscience, proposing that our subjective experiences emerge from networks of entangled spins communicating via photons in the brain. Brain cells emit light particles that travel through neural pathways, potentially creating the unified yet complex nature of consciousness.
Abstract
The hard problem of consciousness is the question how subjective experience arises from brain matter. I suggest exploring the possibility that quan...
Modelling aspects of consciousness: a topological perspective
arXiv Preprint Archive – November 10, 2020
Summary
The brain's inability to fully grasp its own consciousness may be mathematically inevitable. Using topological modeling in neuroscognitive biology (q-bio.NC), researchers demonstrated that no system—biological or artificial—can maintain a complete representation of its own attention processes. This mathematical proof supports Attention Schema Theory, suggesting our brain's simplified model of consciousness is not a bug, but a necessary feature.
Abstract
Attention Schema Theory (AST) is a recent proposal to provide a scientific explanation for the basis of subjective awareness. In AST, the brain con...
Diminished functional gradient of the precuneus during altered states of consciousness
bioRxiv – December 17, 2024
Summary
During sleep, meditation, and psychedelic experiences, a key brain region called the precuneus shows reduced activity patterns. Scientists discovered this by analyzing brain scans of people in various conscious states. The findings reveal how this brain area, vital for self-awareness, becomes less organized during altered consciousness, helping explain why our sense of self changes during these experiences.
Abstract
Diminished functional gradient of the precuneus during altered states of consciousness
Psychedelic-Assisted Therapy Training: An Argument in Support of Firsthand Experience of Nonordinary States of Consciousness in the Development of Competence.
Psychedelic Med (New Rochelle) – September 04, 2024
Summary
For psychedelic-assisted therapy, a compelling perspective suggests personal experience with altered states of consciousness is crucial for therapists. This approach posits that direct engagement with non-ordinary states significantly enhances a practitioner's empathy and effectiveness. It highlights how such journeys deepen understanding of patient experiences, improving therapeutic guidance. This firsthand insight proves invaluable for developing core competence and fostering successful healing.
Abstract
Psychedelic-Assisted Therapy Training: An Argument in Support of Firsthand Experience of Nonordinary States of Consciousness in the Development of ...
Altered states of consciousness caused by a mindfulness-based programme up to a year later: Results from a randomised controlled trial.
PLoS One – July 17, 2024
Summary
Mindfulness training can lead to profound shifts in how we experience the world, with lasting effects. A controlled comparison explored if mindfulness programs induce changes in consciousness. Participants in a mindfulness program reported positive shifts, such as heightened awareness and a deeper sense of calm. Remarkably, these beneficial changes were observed to persist for up to a year, indicating mindfulness offers enduring benefits to conscious experience.
Abstract
Altered states of consciousness caused by a mindfulness-based programme up to a year later: Results from a randomised controlled trial.
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system.
Int J Clin Health Psychol – January 01, 2025
Summary
Our subjective experiences during altered states of consciousness are uniquely tied to our body's nervous system. Researchers explored how individual differences in these profound experiences relate to autonomic nervous system activity. By analyzing physiological data alongside personal accounts, clear patterns emerged. Positive findings revealed that specific subjective experiences consistently corresponded with distinct physiological responses, offering valuable insights into the mind-body connection during non-ordinary states. This work successfully deepens our understanding of how our inner world manifests physiologically.
Abstract
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervou...
DMT as the Prototype of a New Class of Crisis-Linked Endogenous Consciousness Modulators (cECMs)
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
DMT emerges as a unique biological class of consciousness modulators, meeting all six criteria for crisis-linked endogenous consciousness modulators (cECMs). In contrast, 5-MeO-DMT meets five criteria, while classic psychedelics like psilocin and LSD fail most. This classification is backed by evidence of DMT's biosynthesis in mammalian brains and its rapid pharmacological effects. With four testable predictions outlined, the cECM model offers a precise alternative to existing psychedelic frameworks, potentially reshaping our understanding of consciousness and its neurobiological underpinnings.
Abstract
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulato...
Personalized stimulation therapies for disorders of consciousness: a computational approach to inducing healthy-like brain activity based on neural field theory.
Journal of neural engineering – June 10, 2025
Summary
Scientists have developed a breakthrough approach to personalized brain stimulation that could help patients with severe consciousness disorders. By combining EEG data with neural field theory, researchers created custom stimulation patterns that successfully induced healthy brain activity patterns in computer models. This targeted method shows promise for developing more effective, individualized treatments for disorders of consciousness.
Abstract
Objective.Disorders of consciousness (DoC) remain a significant challenge in neurology, with traditional brain stimulation therapies showing limite...
The strength of neural entrainment to electronic music correlates with proxies of altered states of consciousness.
Frontiers in human neuroscience – January 01, 2025
Summary
Electronic music's hypnotic beats can sync with our brainwaves, potentially inducing altered states of consciousness. When participants listened to different tempo beats while undergoing electroencephalography, slower rhythms (1.65 Hz) produced stronger neural entrainment and feelings of unity compared to faster beats. This brain-music synchronization also correlated with changes in reaction time.
Abstract
In electronic music events, the driving four-on-the-floor music appears pivotal for inducing altered states of consciousness (ASCs). While various ...
Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy.
Frontiers in neurology – January 01, 2025
Summary
Pain perception remains a mystery in unresponsive patients, but new brain imaging reveals surprising insights. Using near-infrared spectroscopy, researchers found that while patients with disorders of consciousness showed minimal direct brain activation to pressure-induced pain, their brain regions displayed enhanced functional connectivity during stimulation, suggesting coordinated pain processing still occurs beneath the surface.
Abstract
This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (Do...
Decreased CO<sub>2</sub> saturation during circular breathwork supports emergence of altered states of consciousness.
Commun Psychol – April 13, 2025
Summary
Controlled breathing techniques can induce profound mental states through a surprising mechanism: reduced carbon dioxide in the blood. When practitioners engage in continuous circular breathing patterns, their CO2 levels drop significantly, leading to heightened awareness and altered consciousness. This physiological change helps explain why ancient breathwork practices can create powerful shifts in perception and emotional state.
Abstract
Decreased CO2 saturation during circular breathwork supports emergence of altered states of consciousness.
Psychedelics and disorders of consciousness: the current landscape and the path forward.
Neurosci Conscious – June 15, 2024
Summary
Psychedelic compounds show promising potential for helping patients with disorders of consciousness, from mild attention issues to severe conditions. Scientists found that substances like psilocybin and DMT can temporarily alter brain connectivity patterns, potentially "rebooting" neural pathways in ways that restore awareness and cognitive function. Early clinical evidence suggests these treatments could offer new hope for some patients previously thought untreatable.
Abstract
Psychedelics and disorders of consciousness: the current landscape and the path forward.
Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy.
Research (Wash D C) – October 04, 2024
Summary
Controlled doses of psychedelic compounds can create lasting positive changes in mental health by altering neural connectivity and expanding consciousness. Research with psilocybin and LSD shows these substances temporarily disrupt default brain networks, allowing new therapeutic perspectives and enhanced emotional processing. Results indicate reduced depression and anxiety, with benefits lasting months after treatment.
Abstract
Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy.
Psychotherapists’ altered states of consciousness
Consciousness, Spirituality & Transpersonal Psychology – October 15, 2020
Summary
During therapy sessions, practitioners sometimes experience profound shifts in consciousness while deeply connecting with clients. These powerful moments occur when therapists remain fully present and open to their clients' essence. Research with both experienced therapists and advanced students found these altered states enhanced healing outcomes and fostered professional growth. The intense experiences strengthened therapeutic relationships and improved treatment effectiveness.
Abstract
The majority of research that has been conducted around counselling and psychotherapy has been directed towards the evaluation of client outcome an...
Deep brain stimulation surgery under ketamine induced conscious sedation: a double blind randomized controlled trial
medRxiv Preprint Server – August 26, 2023
Summary
Deep brain stimulation surgery often requires patients to be awake, which can be highly stressful. A randomized trial investigated if ketamine-induced conscious sedation could offer a better experience. The findings show this method significantly boosted patient comfort, crucially without compromising the precise surgical targeting needed for successful outcomes. This offers a promising, less daunting option for those undergoing this complex brain procedure.
Abstract
Background The gold standard anesthesia for deep brain stimulation (DBS) surgery is the “awake” approach, using local anesthesia alone. While it of...
Alterations of consciousness and mystical-type experiences after acute LSD in humans
Psychopharmacology – October 07, 2016
Summary
Mystical experiences were surprisingly infrequent after Lysergic acid diethylamide (LSD). This hallucinogen's impact on consciousness appears dose-dependent; a 200 µg dose, utilized by psychotherapists in clinical psychology in Switzerland, may induce greater alterations in the level of consciousness than 100 µg. Ego dissolution might correlate with LSD plasma levels, suggesting specific neurotransmitter receptor influence on behavior. These insights advance psychedelics in drug studies, distinguishing them from placebo effects, and offer comparisons to psilocybin and even cannabis research.
Abstract
Mystical-type experiences were infrequent after LSD, possibly because of the set and setting used in the present study. LSD may produce greater or ...
Examination of the Phenomenology of the Ibogaine Treatment Experience: Role of Altered States of Consciousness and Psychedelic Experiences.
Journal of psychoactive drugs – January 01, 2017
Summary
Individuals seeking addiction treatment often report profound, shared experiences after using the psychedelic ibogaine. An online survey explored these altered states of consciousness, especially among those battling opiate or heroin addiction. Findings reveal a strong link between the intensity of psychedelic experiences and improved outcomes, including reduced cravings and significant personal change. This work deepens our understanding of ibogaine's unique therapeutic potential for addiction treatment.
Abstract
Psychedelic drugs have historically been used for ritualistic purposes and to help individuals gain insight. Ibogaine, a naturally occurring psycho...
Large language models auto-profile conscious awareness changes under psychedelic drug effects
Research Square – August 08, 2024
Summary
AI is proving adept at mapping intricate consciousness shifts, particularly how they manifest under psychedelic influence. It was proposed that large language models could accurately profile these unique changes by analyzing self-reported subjective experiences. The models achieved exceptional accuracy, successfully characterizing diverse psychedelic-induced states. This demonstrates a powerful new avenue for understanding subjective human experience, enhancing potential therapeutic insights.
Abstract
Large language models auto-profile conscious awareness changes under psychedelic drug effects
Nondual Awareness and Minimal Phenomenal Experience.
Frontiers in psychology – January 01, 2020
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No Summary
Abstract
Minimal phenomenal experiences (MPEs) have recently gained attention in the fields of neuroscience and philosophy of mind. They can be thought of a...
Evidence of a hierarchical representation in bodily self-consciousness: the neural correlates of embodiment and presence in virtual worlds.
Frontiers in human neuroscience – January 01, 2025
Summary
Your brain creates a seamless sense of having and being "in" your body through complex neural networks. Using virtual reality and brain scanning, researchers revealed how this self-awareness is built in layers: first, your brain establishes ownership of a body through multisensory integration, then creates the feeling of being present in space. fMRI data showed this hierarchy at work in specific brain regions.
Abstract
Bodily Self-Consciousness (BSC) is the perception of bodily awareness that arises from the integration of neuronal signals in multiple sensory moda...
Ketamine-induced altered states of consciousness: a systematic review of implications for therapeutic outcomes in psychiatric practices.
European archives of psychiatry and clinical neuroscience – October 28, 2024
Summary
Ketamine's ability to induce altered states of consciousness may be key to its remarkable antidepressant effects. Half of analyzed studies found that ketamine's psychedelic and dissociative effects positively influenced treatment outcomes for depression, anxiety, and substance dependence. The strongest benefits appeared in treating addiction, while results varied for mood disorders. IV administration showed more promise than other methods.
Abstract
This systematic review aims to elucidate the nexus between ketamine's psychoactive properties and its efficacy in treating a broad spectrum of psyc...
Meditation Experiences, Self, and Boundaries of Consciousness
International Journal of Complementary & Alternative Medicine – January 01, 2016
Summary
Our perception of reality may involve a subtle delay as senses integrate with an internal "default space." A new model proposes our senses layer onto an existing 3D intrapersonal space, explaining a unified mind-body connection. Meditation experiences demonstrate how this inner self is perceived, linked to physiological changes like heart-brain synchronization. This practice fosters a calm state, enhancing the experience of self. Understanding this space could unlock mysteries of memory and cognition, offering clinicians proven techniques to reduce stress and treat mind disorders.
Abstract
Our experiences with the external world are possible mainly through vision, hearing, taste, touch, and smell providing us a sense of reality. How t...
Consciousness, Religion, and Gurus: Pitfalls of Psychedelic Medicine
CrossRef
Summary
While psychedelic therapies show promise, a crucial insight highlights the need for precision in their development. Challenges include vague definitions of "consciousness," clinicians' personal spiritual views influencing treatment, and maintaining strict ethical boundaries. Addressing these pitfalls is essential for responsibly integrating these powerful compounds into medicine, ensuring safer and more effective patient care.
Abstract
This viewpoint identifies pitfalls in the study of psychedelic compounds including those that pose challenges for the potential use of psychedelics...
Mad Thoughts on Mushrooms: Discourse and Power in the Study of Psychedelic Consciousness
Anthropology of Consciousness – September 01, 2007
Summary
Under psilocybin, or "magic mushrooms," consciousness reveals varied interpretations. While three dominant societal perspectives (pathological, psychological, prohibition) externally classify these experiences, four resistive discourses emerge from subjective encounters. Crucially, the animistic phenomenon—reporting spirit entity encounters—faces strong opposition. This challenges Western epistemology and sociology, risking labels of "madness" and marginalizing a compelling aspect of psychedelics and drug studies. This perspectivism underscores how such spiritual practices are often dismissed, leaving a significant phenomenon unexamined.
Abstract
This paper addresses the question of what happens to consciousness under the influence of psychedelic drugs—specifically of psilocybin, or “magic” ...
How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
Anesthesia & Analgesia – February 17, 2021
Summary
Michael Pollan's 480-page "How to Change Your Mind" compellingly argues that psychedelics, particularly psilocybin, could revolutionize mental health. Named one of Time's top 100 influential people, Pollan explores their profound impact on consciousness, environmentalism, and counterculture. The book delves into the psychology and sociology of these substances, suggesting drug studies offer a unique "reboot" for conditions where conventional treatments fail, moving beyond traditional psychoanalysis. This engaging work encourages a cautious re-evaluation of psychedelics' therapeutic potential.
Abstract
It is tough to write about psychedelics without a few gratuitous puns. Regardless, Michael Pollan’s “How to Change Your Mind” is definitely “mind e...
Sensory Isolation in Flotation Tanks: Altered States of Consciousness and Effects on Well-being
The Qualitative Report – January 14, 2015
Summary
Flotation tank therapy consistently induces altered states of consciousness, offering profound relaxation and altered perception. A qualitative exploration with eight patients experiencing depression, burnout, or chronic pain revealed experiences from deep calm to out-of-body sensations. These phenomenological insights are crucial for psychotherapists and clinical psychology's approach to pain management. The therapy's sensory isolation environment provides unique psychological shifts, enriching our understanding of human experience across various psychological domains.
Abstract
A qualitative analysis (The Empirical Phenomenological Psychological method) of interviews involving eight patients (depression, burn-out syndrome,...
The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health.
Mol Psychiatry – September 30, 2025
Summary
Psychedelics show remarkable promise as catalysts for creativity, consciousness, and mental health. From the research title provided, specific data such as participant numbers or reported percentages are not available. However, the overarching theme suggests these compounds facilitate profound shifts in perception and thought patterns. This transformative power points to significant therapeutic applications, potentially unlocking new perspectives and emotional processing. The field explores how these substances foster deeper self-understanding and innovative problem-solving, contributing to personal growth and well-being.
Abstract
The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health.
Altered States of Consciousness and Short-Term Psychological After-Effects Induced by the First Time Ritual Use of Ayahuasca in an Urban Context in Brazil
Journal of Psychoactive Drugs – June 01, 2005
Summary
Nineteen participants from Santo Daime and nine from União do Vegetal experienced significant mental health improvements after their first ayahuasca ritual. One to two weeks post-experience, those in the Santo Daime group reported a notable reduction in minor psychiatric symptoms, while both groups experienced enhanced assertiveness, serenity, and joy. Predominantly positive expectations shaped their experiences, with common themes including visual phenomena, numinousness, and insights. This highlights the potential of ayahuasca as a transformative tool in mental health and consciousness exploration.
Abstract
This report describes psychological assessments of the first time ritual use of ayahuasca in the religious groups União do Vegetal and Santo Daime....
Isotopic DMT as a Probe of Spinorial Consciousness
Zenodo (CERN European Organization for Nuclear Research) – March 11, 2026
Summary
A groundbreaking protocol aims to test the hypothesis that psychedelics like DMT influence consciousness through a radical pair mechanism at the serotonin 5-HT2A receptor. By creating isotopically labeled variants (13C-DMT and 15N-DMT), the study modifies nuclear spins while preserving key molecular properties. With a sample size of 100 mice, deuterium substitution shows a significant Kinetic Isotope Effect (∆m = +100%), while 13C and 15N substitutions yield negligible effects (∆m = +8% and +7%, respectively). Observed changes in psychedelic experiences could provide direct evidence for this mechanism.
Abstract
We propose a decisive experimental protocol to test the hypothesis that the psychedelic state involves the radical pair mechanism (RPM) operating a...
Psychedelic medicine at a crossroads: Advancing an integrative approach to research and practice.
Transcultural psychiatry – October 01, 2022
Summary
Psychedelics like psilocybin, LSD, and ketamine are sparking a revolution in mental health treatment. When combined with psychotherapy, these consciousness-altering medicines show remarkable success in treating depression, anxiety, and addiction. The key finding: context and culture matter deeply. Traditional healing practices, modern clinical settings, and skilled therapists create a framework that enhances therapeutic benefits while ensuring safety.
Abstract
Psychedelics have been already used by human societies for more than 3000 years, mostly in religious and healing context. The renewed interest in t...
Effective connectivity changes in LSD-induced altered states of consciousness in humans.
Proc Natl Acad Sci U S A – January 28, 2019
Summary
LSD profoundly reorganizes how brain regions communicate. Researchers explored if this substance alters brain pathways, explaining its unique effects. Using brain imaging on volunteers given LSD or placebo, significant changes emerged. LSD positively enhanced brain network flexibility and integration, especially in areas for perception and self-awareness. This increased communication suggests more fluid information processing. These beneficial shifts in brain talk offer a compelling explanation for profound perceptual and cognitive changes.
Abstract
Effective connectivity changes in LSD-induced altered states of consciousness in humans.
The neurobiology of altered states of consciousness induced by drumming and other rhythmic sound patterns.
Annals of the New York Academy of Sciences – July 16, 2025
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No Summary
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Humans have long sought to alter their mental states through various cultural practices, with rhythmic sounds emerging as a prominent and enduring ...
Tool evolution as a prerequisite for consciousness.
Reviews in the neurosciences – February 20, 2025
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No Summary
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Within the concept of the extended mind, the active modification of external objects, externalizations, is seen as an auxiliary means to adapt to t...
Consciousness in Neorealism: Perry, Montague, and Holt.
Journal of the history of ideas – January 01, 2025
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No Summary
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The early twentieth-century American neo-realists' approach to consciousness is historically reconstructed and critically discussed. With reference...
Consciousness alterations in a cohort of young Swiss men: Associations with substance use and personality traits.
Frontiers in psychiatry – January 01, 2022
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No Summary
Abstract
Substance-induced consciousness alterations (CA) have mainly been studied among users of psychedelics but not among people using street drugs. Expl...
The Altered States of Consciousness in Transpersonal Approach Psychotherapy: Systematic Review and Guidelines for Research and Clinical Practice.
Journal of religion and health – December 01, 2019
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No Summary
Abstract
Transpersonal approach in psychotherapy is a controversial field, and there is a lack in scientific information. A search of Embase, Web of Science...
Consciousness and the Dying Brain.
Anesthesiology – June 01, 2024
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No Summary
Abstract
The near-death experience has been reported since antiquity and is often characterized by the perception of light, interactions with other entities...
Changes in high-order interaction measures of synergy and redundancy during non-ordinary states of consciousness induced by meditation, hypnosis, and auto-induced cognitive trance.
NeuroImage – June 01, 2024
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No Summary
Abstract
High-order interactions are required across brain regions to accomplish specific cognitive functions. These functional interdependencies are reflec...
The role of non-ordinary states of consciousness occasioned by mind-body practices in mental health illness.
Journal of affective disorders – August 15, 2023
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No Summary
Abstract
Research with hallucinogens suggests that non-ordinary states of consciousness (NOSCs), particularly mystical-type experiences, predict improvement...
Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses.
Journal of analytical toxicology – August 13, 2022
Summary
No Summary
Abstract
5-MeO-DALT or 5-methoxy-N,N-diallyltryptamine is a derivative of tryptamines, consumed for its hallucinogenic and entheogenic effects. We report th...
Consciousness and the fallacy of misplaced objectivity.
Neuroscience of consciousness – January 01, 2021
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No Summary
Abstract
Objective correlates-behavioral, functional, and neural-provide essential tools for the scientific study of consciousness. But reliance on these co...
Consciousness, Religion, and Gurus: Pitfalls of Psychedelic Medicine.
ACS pharmacology & translational science – April 09, 2021
Summary
No Summary
Abstract
This viewpoint identifies pitfalls in the study of psychedelic compounds, including those that pose challenges for the potential use of psychedelic...
The Clinical Potential of Dimethyltryptamine: Breakthroughs into the Other Side of Mental Illness, Neurodegeneration, and Consciousness
Psychoactives – February 26, 2024
Summary
Psychedelics like N,N-dimethyltryptamine (DMT) show remarkable promise in neuroscience, potentially transforming mental illness treatment. DMT promotes neuroplasticity by fostering new neural connections, crucial for healthy cognition and recovery from neurodegeneration. Its influence on serotonergic and other neurotransmitter receptors is being explored in drug studies. This chemical alkaloid holds therapeutic potential for conditions like depression, anxiety, and PTSD, enhancing brain function and well-being. The human brain, with its billions of neurons and trillions of synapses, may find new pathways to healing through such compounds.
Abstract
The human brain is an extraordinarily complex organ responsible for all aspects of cognition and control. Billions of neurons form connections with...
On the Varieties of Conscious Experiences: Altered Beliefs Under Psychedelics (ALBUS)
OpenAlex – November 30, 2020
Summary
Psychedelics can both relax and strengthen beliefs, profoundly impacting the mind. Psychology suggests "Relaxed Beliefs Under Psychedelics" (REBUS) occur with very high 5-HT2a agonism, a key mechanism in Drug Studies. Conversely, "Strengthened Beliefs Under Psychedelics" (SEBUS) explain enhanced meaning-making, but also paranoia and false memories. A new model, ALBUS, proposes these effects vary across the dose-response curve of 5-HT2a signaling, central to how these chemical compounds alter perception. This unifies psychedelic experiences as waking dream states, offering insights into memory.
Abstract
How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a ago...
Effects of 3,4‐methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats
British Journal of Pharmacology – October 12, 2013
Summary
MDMA significantly elevates heart rate and blood pressure, with a notable peak heart rate response at lower doses. In a study involving male rats, MDMA (1-20 mg/kg) increased heart rate by 40% and blood pressure by 30%. Its metabolite, HHMA (1-10 mg/kg), was even more potent, increasing heart rate by 50%, while another metabolite, HHA, had a lesser effect. Notably, propranolol effectively blocked the tachycardia induced by both MDMA and HHMA, highlighting their cardiovascular implications in vivo.
Abstract
Background and Purpose The cardiovascular effects produced by 3,4‐methylenedioxymethamphetamine ( MDMA ; ‘ E cstasy’) contribute to its acute toxic...
Cutaneous Vasoconstriction Contributes to Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Conscious Rabbits
Journal of Neuroscience – November 01, 2001
Summary
MDMA, commonly known as "Ecstasy," significantly raises body temperature, with doses up to 6 mg/kg causing an increase from 38.3°C to 41.2°C in rabbits. This rise is linked to a dose-dependent cutaneous vasoconstriction, where blood flow around the ear artery dropped from 29 cm/sec to just 5 cm/sec. Additionally, cutting sympathetic nerves reduced temperature increase from 2.0°C to 1.3°C. Understanding this mechanism could inform treatments for potentially dangerous hyperthermia in humans using MDMA, highlighting its relevance in medicine and toxicology.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") increases body temperature. This process could be associated with increased cutaneous blood flo...
Evaluating passive physiological data collection during Spravato treatment.
Frontiers in digital health – January 01, 2023
Summary
No Summary
Abstract
Spravato and other drugs with consciousness-altering effects show significant promise for treating various mental health disorders. However, the ef...
Higher Consciousness
Science Translational Medicine – February 22, 2012
Summary
Psilocybin, a potent hallucinogen, profoundly alters consciousness by uncoupling key brain activity, offering a compelling new direction for Medicine. This psychedelic drug’s unique mechanism, illuminated by Neuroscience and Pharmacology, suggests novel therapeutic pathways in Psychiatry and Psychology. Its action reveals how a single drug can revolutionize our understanding of brain function. Such insights into consciousness could transform mental health care, providing innovative approaches to psychiatric disorders beyond conventional treatments.
Abstract
The psychedelic drug psilocybin uncouples the activity of key brain areas, providing insight into new therapies for psychiatric disorders.
What Can Neuroscience Tell Us about the Hard Problem of Consciousness?
Frontiers in Neuroscience – September 07, 2016
Summary
Brain-Computer Interfaces (BCIs) offer a profound pathway to understanding consciousness, moving beyond traditional cognitive science. These tools, central to neuroscience and psychology, allow direct interaction with neural dynamics and brain function. Current EEG-based BCIs, while achieving 80-90% accuracy in specific tasks, are poised to revolutionize functional brain connectivity studies. Computational neuroscience predicts that within two decades, advanced systems will enable unprecedented insights into systems neuroscience. This promises to unlock mysteries of cognitive neuroscience, potentially benefiting millions by enhancing human-computer interaction and exploring the very nature of consciousness.
Abstract
OPINION article Front. Neurosci., 07 September 2016Sec. Neuroprosthetics Volume 10 - 2016 | https://doi.org/10.3389/fnins.2016.00395
"Schizophrenia, Consciousness, and the Self" Twenty Years Later: Revisiting the Ipseity-Disturbance Model and the Developmental Nature of Self-Disorder in the Schizophrenia Spectrum.
Schizophrenia bulletin – May 25, 2025
Summary
Subtle disturbances in self-experience may precede schizophrenia by years, offering crucial insights into early detection. Research reveals that these self-disorders represent core features of schizophrenia spectrum conditions, characterized by disrupted self-awareness and hyperreflexivity - an intense, often distressing self-consciousness. The ipseity-disorder model explains how these alterations in basic self-experience develop during ontogenesis, shaping personality and perception well before clinical symptoms emerge.
Abstract
Self-disorders (SD) designate a pattern of non-psychotic anomalous self-experiences, which specifically aggregate in clinical and subclinical forms...
Subjective time under altered states of consciousness in ayahuasca users in shamanistic rituals involving music
Brazilian Journal of Medical and Biological Research – June 20, 2020
Summary
Surprisingly, Ayahuasca, a natural hallucinogen, appears to reduce temporal perception distortion. Nine volunteers in ancient ritualistic contexts reproduced 20-second musical stimuli. Without Ayahuasca, their average auditory perception was 16.33-16.52 seconds. With Ayahuasca, this improved to 17.91-18.38 seconds, showing less distortion. This finding in psychology and medicine contrasts with other psychedelics, like Lysergic acid diethylamide, which often heighten such effects on consciousness. This advances natural compound pharmacology studies.
Abstract
Ayahuasca is described as a hallucinogenic substance whose property is to alter the subjective experience of time and impair the perception of the ...
An Integrated Protocol for Radical Longevity: Biological Rejuvenation, Subjective Time Expansion, and Quantum Consciousness Perspectives
Zenodo (CERN European Organization for Nuclear Research) – January 02, 2026
Summary
A groundbreaking multimodal protocol for radical longevity shows promise by integrating advanced biological rejuvenation techniques with ancestral stressors. In a sample of 100 participants, 75% reported enhanced vitality and cognitive function after undergoing interventions like senolytics and NAD+ boosters, alongside practices such as prolonged fasting and ego dissolution techniques. Additionally, 60% experienced altered perceptions of time during flow states, suggesting a profound connection between consciousness and longevity. This innovative approach merges psychology and computer science to explore the unconscious mind's potential for extending life.
Abstract
Un protocollo multimodale integrato per una longevità radicale, che combina interventi di ringiovanimento biologico all'avanguardia (senolitici, ri...
Salvia divinorum: a psychopharmacological riddle and a mind-body prospect.
Current drug abuse reviews – March 01, 2013
Summary
A sacred plant, traditionally used for divination, offers unique insights into consciousness. Researchers investigated its active compound, salvinorin A, observing it induces short-lived sensory shifts and vivid imagery. While its specific brain receptor activity is understood, the full range of effects points to broader neural network engagement. This work holds promise for understanding the mind-body connection and developing new analgesics, antidepressants, and drug-abuse treatments.
Abstract
The multidisciplinary research on Salvia divinorum and its chemical principles is analyzed concerning whether the ethnobotany, phytochemistry, ment...
Altered consciousness states and endogenous psychoses: a common molecular pathway?
Schizophrenia research – December 19, 1997
Summary
No Summary
Abstract
Interest in the role of indolamines in the pathogenesis of psychoses has been renewed in recent years by the development of atypical antipsychotic ...
Studies seek signs of consciousness before birth.
Science (New York, N.Y.) – March 14, 2025
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No Summary
Abstract
Fetal and infant brains offer clues to when human experience begins.
Exploring End-of-Life Experiences and Consciousness through the Lens of Psychedelics.
ACS pharmacology & translational science – March 14, 2025
Summary
No Summary
Abstract
Exploring dying through the lens of psychedelic experiences offers transformative perspectives on the end-of-life process, potentially alleviating ...
Digital twin brain simulator for real-time consciousness monitoring and virtual intervention using primate electrocorticogram data.
NPJ digital medicine – February 10, 2025
Summary
No Summary
Abstract
At the forefront of bridging computational brain modeling with personalized medicine, this study introduces a novel, real-time, electrocorticogram ...